Seroatlas · Human Serome Atlas

CAPS2

Calcyphosin-2

Also known as: CAYP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXY5
Gene: CAPS2
Ensembl: ENSG00000180881
Chromosome: 12
Canonical length: 538 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Vesicles,Centrosome

OverviewNCBI Gene

Calcyphosine-2 is a calcium-binding protein with 2 EF-hand motifs (Wang et al., 2002 [PubMed 11846421]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

538 residues, UniProt reviewed canonical sequence.

>Q9BXY5|CAPS2
     1  MDLEVKGVAA TSRSQIQPFF GRKKPLQQRW TSESWTNQNS CPPVVPRLDL GSLVDSDDED
    61  NFSYIPLSTA NLPNSSSTLG WVTPCQTPYT QYHLNKLDQN IIPENLPAPT DKCKLKYQQC
   121  KTEIKEGYKQ YSQRNAENTK SNVTHKQSPR NKIDEKCVQD EEANTDDLTT LDRKAILQQG
   181  YADNSCDKQQ RARKLDAEIV AAEKKKQIVA EQVMIDHLSR AVISDPEQNL AIEQKESDHI
   241  LPDSKMTPLR FRKRTLHETK IRTHSTLTEN VLSHKLQFDG RIVSRNGRDA CRELIGFFFT
   301  HDQSLTIYEY RQFGKNRTNV LPFIQKSIYS HQCGRRKGKQ YRLGDFYVGA TLTFLSSDHL
   361  SLPESIKENT LLKLRITNID QIALDSLKTA SMEQEDDIII QETNDRLVFK AIQDVLKEKL
   421  HKRGVRILTG LGKYFQQLDK EGNGLLDKAD FKQALKVFHL EVSEKDFESA WLILNDNGNG
   481  KVDYGEFKRG IIGEMNEYRK SYVRKAFMKL DFNKSGSVPI INIRKCYCAK KHSQVISG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAPS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 9.4 nTPM

Expression across tissuesHPA

Tissue

retina: 9.4 nTPM
fallopian tube: 7.2 nTPM
choroid plexus: 5.7 nTPM
epididymis: 3.2 nTPM
testis: 3.1 nTPM
parathyroid gland: 2.8 nTPM

Single-cell type

ependymal cells: 351 nCPM
lactotrophs: 265 nCPM
choroid plexus epithelial cells: 257 nCPM
gonadotrophs: 251 nCPM
respiratory ciliated cells: 208 nCPM
bergmann glia: 191 nCPM

Immune cell

NK-cell: 0.2 nTPM
T-reg: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 24 nTPM
medulla oblongata: 16 nTPM
midbrain: 14 nTPM
cerebral cortex: 13 nTPM
hypothalamus: 12 nTPM
spinal cord: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: -0.09
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

calcium ion binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAPS2 as an antibody target. Whether an autoantibody or antibody against CAPS2 could matter depends on whether native CAPS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAPS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CAPS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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