Seroatlas · Human Serome Atlas

CAPS

Calcyphosin

Also known as: CAPS1, CAYP1_HUMAN, MGC126562

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13938
Gene: CAPS
Ensembl: ENSG00000105519
Chromosome: 19
Canonical length: 275 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a calcium-binding protein, which may play a role in the regulation of ion transport. A similar protein was first described as a potentially important regulatory protein in the dog thyroid and was termed as R2D5 antigen in rabbit. Alternative splicing of this gene generates two transcript variants. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

275 residues, UniProt reviewed canonical sequence.

>Q13938|CAPS
     1  MQCHRDLALS QALWGWQLSK QSGWAHPSLP HSPLPSTVHS CSWAPPHLQR HLPLATVSPG
    61  TTQLTQGPAG RTLGQTQASC PEPRPSMDAV DATMEKLRAQ CLSRGASGIQ GLARFFRQLD
   121  RDGSRSLDAD EFRQGLAKLG LVLDQAEAEG VCRKWDRNGS GTLDLEEFLR ALRPPMSQAR
   181  EAVIAAAFAK LDRSGDGVVT VDDLRGVYSG RAHPKVRSGE WTEDEVLRRF LDNFDSSEKD
   241  GQVTLAEFQD YYSGVSASMN TDEEFVAMMT SAWQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAPS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 315 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 315 nTPM
choroid plexus: 113 nTPM
hippocampal formation: 81 nTPM
hypothalamus: 76 nTPM
basal ganglia: 65 nTPM
spinal cord: 64 nTPM

Single-cell type

fallopian tube ciliated cells: 4,685 nCPM
epididymal efferent duct ciliated cells: 3,325 nCPM
respiratory ciliated cells: 3,276 nCPM
endometrial ciliated cells: 2,808 nCPM
ependymal cells: 709 nCPM
endometrial luminal cells: 483 nCPM

Immune cell

naive B-cell: 1.8 nTPM
NK-cell: 1.8 nTPM
gdT-cell: 1.7 nTPM
plasmacytoid DC: 1.5 nTPM
memory CD8 T-cell: 1.3 nTPM
memory CD4 T-cell: 1 nTPM

Brain region

midbrain: 198 nTPM
medulla oblongata: 158 nTPM
hypothalamus: 124 nTPM
white matter: 109 nTPM
spinal cord: 104 nTPM
pons: 95 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.79
gnomAD pLI: 0
gnomAD missense Z: -0.49
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

intracellular signal transduction

Molecular functions

calcium ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAPS as an antibody target. Whether an autoantibody or antibody against CAPS could matter depends on whether native CAPS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAPS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CAPS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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