Seroatlas · Human Serome Atlas

CAPRIN2

Caprin-2

Also known as: C1QDC1, CAPR2_HUMAN, caprin-2, EEG1, FLJ11391, FLJ22569, RNG140

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6IMN6
Gene: CAPRIN2
Ensembl: ENSG00000110888
Chromosome: 12
Canonical length: 1127 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome,Cytosol
Quaternary structure: Homotrimer

OverviewNCBI Gene

The protein encoded by this gene may regulate the transport of mRNA. It may play a role in the differentiation of erythroblasts. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

1127 residues, UniProt reviewed canonical sequence.

>Q6IMN6|CAPRIN2
     1  MEVQVSQASL GFELTSVEKS LREWSRLSRE VIAWLCPSSP NFILNFPPPP SASSVSMVQL
    61  FSSPFGYQSP SGHSEEEREG NMKSAKPQVN HSQHGESQRA LSPLQSTLSS AASPSQAYET
   121  YIENGLICLK HKIRNIEKKK LKLEDYKDRL KSGEHLNPDQ LEAVEKYEEV LHNLEFAKEL
   181  QKTFSGLSLD LLKAQKKAQR REHMLKLEAE KKKLRTILQV QYVLQNLTQE HVQKDFKGGL
   241  NGAVYLPSKE LDYLIKFSKL TCPERNESLS VEDQMEQSSL YFWDLLEGSE KAVVGTTYKH
   301  LKDLLSKLLN SGYFESIPVP KNAKEKEVPL EEEMLIQSEK KTQLSKTESV KESESLMEFA
   361  QPEIQPQEFL NRRYMTEVDY SNKQGEEQPW EADYARKPNL PKRWDMLTEP DGQEKKQESF
   421  KSWEASGKHQ EVSKPAVSLE QRKQDTSKLR STLPEEQKKQ EISKSKPSPS QWKQDTPKSK
   481  AGYVQEEQKK QETPKLWPVQ LQKEQDPKKQ TPKSWTPSMQ SEQNTTKSWT TPMCEEQDSK
   541  QPETPKSWEN NVESQKHSLT SQSQISPKSW GVATASLIPN DQLLPRKLNT EPKDVPKPVH
   601  QPVGSSSTLP KDPVLRKEKL QDLMTQIQGT CNFMQESVLD FDKPSSAIPT SQPPSATPGS
   661  PVASKEQNLS SQSDFLQEPL QATSSPVTCS SNACLVTTDQ ASSGSETEFM TSETPEAAIP
   721  PGKQPSSLAS PNPPMAKGSE QGFQSPPASS SSVTINTAPF QAMQTVFNVN APLPPRKEQE
   781  IKESPYSPGY NQSFTTASTQ TPPQCQLPSI HVEQTVHSQE TAANYHPDGT IQVSNGSLAF
   841  YPAQTNVFPR PTQPFVNSRG SVRGCTRGGR LITNSYRSPG GYKGFDTYRG LPSISNGNYS
   901  QLQFQAREYS GAPYSQRDNF QQCYKRGGTS GGPRANSRAG WSDSSQVSSP ERDNETFNSG
   961  DSGQGDSRSM TPVDVPVTNP AATILPVHVY PLPQQMRVAF SAARTSNLAP GTLDQPIVFD
  1021  LLLNNLGETF DLQLGRFNCP VNGTYVFIFH MLKLAVNVPL YVNLMKNEEV LVSAYANDGA
  1081  PDHETASNHA ILQLFQGDQI WLRLHRGAIY GSSWKYSTFS GYLLYQD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAPRIN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

testis: 17 nTPM
retina: 16 nTPM
cerebellum: 16 nTPM
hypothalamus: 14 nTPM
basal ganglia: 12 nTPM
heart muscle: 12 nTPM

Single-cell type

other brain neurons: 163 nCPM
bergmann glia: 122 nCPM
gonadotrophs: 96 nCPM
cardiomyocytes: 95 nCPM
erythrocyte progenitors: 89 nCPM
fibro-adipogenic progenitors: 85 nCPM

Immune cell

basophil: 2.7 nTPM
memory CD8 T-cell: 2.1 nTPM
memory B-cell: 1.9 nTPM
gdT-cell: 1.8 nTPM
MAIT T-cell: 1.7 nTPM
naive B-cell: 1.5 nTPM

Brain region

hypothalamus: 79 nTPM
cerebral cortex: 48 nTPM
medulla oblongata: 48 nTPM
pons: 44 nTPM
thalamus: 39 nTPM
basal ganglia: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.1
gnomAD missense Z: 0.61
DepMap mean gene effect: -0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CAPRIN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAPRIN2 as an antibody target. Whether an autoantibody or antibody against CAPRIN2 could matter depends on whether native CAPRIN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAPRIN2 is annotated at the cell surface, where native CAPRIN2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CAPRIN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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