CAPNS2
Calpain small subunit 2
Also known as: CPNS2_HUMAN, MGC12536, MGC14804
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96L46
- Gene
- CAPNS2
- Ensembl
- ENSG00000256812
- Chromosome
- 16
- Canonical length
- 248 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
Enables calcium-dependent cysteine-type endopeptidase activity. Predicted to be located in cytosol and plasma membrane. Predicted to be part of calpain complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
248 residues, UniProt reviewed canonical sequence.
>Q96L46|CAPNS2
1 MFLAKALLEG ADRGLGEALG GLFGGGGQRR EGGGRNIGGI VGGIVNFISE AAAAQYTPEP
61 PPTQQHFTSV EASESEEVRR FRQQFTQLAG PDMEVGATDL MNILNKVLSK HKDLKTDGFS
121 LDTCRSIVSV MDSDTTGKLG FEEFKYLWNN IKKWQCVYKQ YDRDHSGSLG SSQLRGALQA
181 AGFQLNEQLY QMIVRRYANE DGDMDFNNFI SCLVRLDAMF RAFKSLDRDR DGLIQVSIKE
241 WLQLTMYSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CAPNS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.35
- Highest tissue expression
- 99 nTPM
Expression across tissuesHPA
Tissue
- skin: 99 nTPM
- esophagus: 83 nTPM
- vagina: 33 nTPM
- cervix: 26 nTPM
- tonsil: 17 nTPM
- urinary bladder: 17 nTPM
Single-cell type
- suprabasal keratinocytes: 0.5 nCPM
- esophageal suprabasal cells: 0.4 nCPM
- esophageal apical cells: 0.3 nCPM
- basal keratinocytes: 0.2 nCPM
- esophageal basal cells: 0.2 nCPM
- ocular epithelial cells: 0.1 nCPM
Immune cell
- eosinophil: 3.8 nTPM
- intermediate monocyte: 1 nTPM
- neutrophil: 0.4 nTPM
- myeloid DC: 0.2 nTPM
- classical monocyte: 0.1 nTPM
- non-classical monocyte: 0.1 nTPM
Brain region
- pons: 4 nTPM
- white matter: 3.9 nTPM
- medulla oblongata: 3.8 nTPM
- spinal cord: 3.1 nTPM
- thalamus: 3 nTPM
- cerebellum: 2.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.36
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.08
- DepMap mean gene effect
- 0.13
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CAPNS2 as an antibody target. Whether an autoantibody or antibody against CAPNS2 could matter depends on whether native CAPNS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CAPNS2 is annotated at the cell surface, where native CAPNS2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label CAPNS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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