Seroatlas · Human Serome Atlas

CAPN15

Calpain-15

Also known as: CAN15_HUMAN, SOLH

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75808
Gene: CAPN15
Ensembl: ENSG00000103326
Chromosome: 16
Canonical length: 1086 aa
Protein class: Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a protein containing zinc-finger-like repeats and a calpain-like protease domain. The encoded protein may function as a transcription factor, RNA-binding protein, or in protein-protein interactions during visual system development. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1086 residues, UniProt reviewed canonical sequence.

>O75808|CAPN15
     1  MATVGEWSCV RCTFLNPAGQ RQCSICEAPR HKPDLNHILR LSVEEQKWPC ARCTFRNFLG
    61  KEACEVCGFT PEPAPGAAFL PVLNGVLPKP PAILGEPKGS CQEEAGPVRT AGLVATEPAR
   121  GQCEDKDEEE KEEQEEEEGA AEPRGGWACP RCTLHNTPVA SSCSVCGGPR RLSLPRIPPE
   181  ALVVPEVVAP AGFHVVPAAP PPGLPGEGAE ANPPATSQGP AAEPEPPRVP PFSPFSSTLQ
   241  NNPVPRSRRE VPPQLQPPVP EAAQPSPSAG CRGAPQGSGW AGASRLAELL SGKRLSVLEE
   301  EATEGGTSRV EAGSSTSGSD IIDLAGDTVR YTPASPSSPD FTTWSCAKCT LRNPTVAPRC
   361  SACGCSKLHG FQEHGEPPTH CPDCGADKPS PCGRSCGRVS SAQKAARVLP ERPGQWACPA
   421  CTLLNALRAK HCAACHTPQL LVAQRRGAAP LRRRESMHVE QRRQTDEGEA KALWENIVAF
   481  CRENNVSFVD DSFPPGPESV GFPAGDSVQQ RVRQWLRPQE INCSVFRDHR ATWSVFHTLR
   541  PSDILQGLLG NCWFLSALAV LAERPDLVER VMVTRSLCAE GAYQVRLCKD GTWTTVLVDD
   601  MLPCDEAGCL LFSQAQRKQL WVALIEKALA KLHGSYFALQ AGRAIEGLAT LTGAPCESLA
   661  LQLSSTNPRE EPVDTDLIWA KMLSSKEAGF LMGASCGGGN MKVDDSAYES LGLRPRHAYS
   721  ILDVRDVQGT RLLRLRNPWG RFSWNGSWSD EWPHWPGHLR GELMPHGSSE GVFWMEYGDF
   781  VRYFDSVDIC KVHSDWQEAR VQGCFPSSAS APVGVTALTV LERASLEFAL FQEGSRRSDA
   841  VDSHLLDLCI LVFRATFGSG GHLSLGRLLA HSKRAVKKFV SCDVMLEPGE YAVVCCAFNH
   901  WGPPLPGTPA PQASSPSAGV PRASPEPPGH VLAVYSSRLV MVEPVEAQPT TLADAIILLT
   961  ESRGERHEGR EGMTCYYLTH GWAGLIVVVE NRHPKAYLHV QCDCTDSFNV VSTRGSLRTQ
  1021  DSVPPLHRQV LVILSQLEGN AGFSITHRLA HRKAAQAFLS DWTASKGTHS PPLTPEVAGL
  1081  HGPRPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAPN15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 33 nTPM
pancreas: 23 nTPM
small intestine: 21 nTPM
skin: 20 nTPM
spleen: 19 nTPM
colon: 18 nTPM

Single-cell type

esophageal apical cells: 52 nCPM
proximal tubule cells: 52 nCPM
pdcs: 49 nCPM
colonocytes: 44 nCPM
enterocytes: 35 nCPM
nk-cells: 30 nCPM

Immune cell

neutrophil: 17 nTPM
basophil: 4.7 nTPM
naive B-cell: 2.3 nTPM
classical monocyte: 1.3 nTPM
non-classical monocyte: 1.3 nTPM
NK-cell: 1.1 nTPM

Brain region

cerebellum: 48 nTPM
cerebral cortex: 36 nTPM
amygdala: 31 nTPM
hippocampal formation: 31 nTPM
thalamus: 29 nTPM
basal ganglia: 28 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CAPN15.

Disease | AllUniProt

Conditions CAPN15 is implicated in, by any mechanism.

Oculogastrointestinal neurodevelopmental syndrome (OGIN) MIM:619318

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 391 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Oculogastrointestinal-neurodevelopmental syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.97
gnomAD missense Z: 1.77
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CAPN15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

UBQLN2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAPN15 as an antibody target. Whether an autoantibody or antibody against CAPN15 could matter depends on whether native CAPN15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAPN15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CAPN15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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