Seroatlas · Human Serome Atlas

CAPN12

Calpain-12

Also known as: CAN12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZSI9
Gene: CAPN12
Ensembl: ENSG00000182472
Chromosome: 19
Canonical length: 719 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Focal adhesion sites

OverviewNCBI Gene

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes a member of the calpain large subunit family. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

719 residues, UniProt reviewed canonical sequence.

>Q6ZSI9|CAPN12
     1  MASSSGRVTI QLVDEEAGVG AGRLQLFRGQ SYEAIRAACL DSGILFRDPY FPAGPDALGY
    61  DQLGPDSEKA KGVKWMRPHE FCAEPKFICE DMSRTDVCQG SLGNCWFLAA AASLTLYPRL
   121  LRRVVPPGQD FQHGYAGVFH FQLWQFGRWM DVVVDDRLPV REGKLMFVRS EQRNEFWAPL
   181  LEKAYAKLHG SYEVMRGGHM NEAFVDFTGG VGEVLYLRQN SMGLFSALRH ALAKESLVGA
   241  TALSDRGEYR TEEGLVKGHA YSITGTHKVF LGFTKVRLLR LRNPWGCVEW TGAWSDSCPR
   301  WDTLPTECRD ALLVKKEDGE FWMELRDFLL HFDTVQICSL SPEVLGPSPE GGGWHVHTFQ
   361  GRWVRGFNSG GSQPNAETFW TNPQFRLTLL EPDEEDDEDE EGPWGGWGAA GARGPARGGR
   421  TPKCTVLLSL IQRNRRRLRA KGLTYLTVGF HVFQIPEELL GLWDSPRSHA LLPRLLRADR
   481  SPLSARRDVT RRCCLRPGHY LVVPSTAHAG DEADFTLRVF SERRHTAVEI DDVISADLQS
   541  LQGPYLPLEL GLEQLFQELA GEEEELNASQ LQALLSIALE PARAHTSTPR EIGLRTCEQL
   601  LQCFGHGQSL ALHHFQQLWG YLLEWQAIFN KFDEDTSGTM NSYELRLALN AAGFHLNNQL
   661  TQTLTSRYRD SRLRVDFERF VSCVAHLTCI FCHCSQHLDG GEGVICLTHR QWMEVATFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAPN12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

liver: 26 nTPM
gallbladder: 21 nTPM
salivary gland: 5 nTPM
cervix: 4.9 nTPM
fallopian tube: 4 nTPM
skin: 3.8 nTPM

Single-cell type

proximal tubule cells: 134 nCPM
papillary tip epithelial cells: 13 nCPM
podocytes: 12 nCPM
tuft cells: 12 nCPM
loop of henle epithelial cells: 8.2 nCPM
gastric chief cells: 7.6 nCPM

Immune cell

basophil: 59 nTPM
NK-cell: 26 nTPM
gdT-cell: 4.5 nTPM
MAIT T-cell: 4.4 nTPM
naive B-cell: 3.9 nTPM
eosinophil: 3.6 nTPM

Brain region

hypothalamus: 1.3 nTPM
pons: 1.1 nTPM
cerebral cortex: 0.7 nTPM
medulla oblongata: 0.7 nTPM
basal ganglia: 0.6 nTPM
amygdala: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.52
gnomAD pLI: 0
gnomAD missense Z: -1.26
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAPN12 as an antibody target. Whether an autoantibody or antibody against CAPN12 could matter depends on whether native CAPN12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAPN12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CAPN12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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