Seroatlas · Human Serome Atlas

CAPN11

Calpain-11

Also known as: CAN11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UMQ6
Gene: CAPN11
Ensembl: ENSG00000137225
Chromosome: 6
Canonical length: 739 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Acrosome,Equatorial segment,Mid piece,Principal piece,End piece

OverviewNCBI Gene

Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008]

Canonical amino-acid sequenceUniProt

739 residues, UniProt reviewed canonical sequence.

>Q9UMQ6|CAPN11
     1  MLYSPGPSLP ESAESLDGSQ EDKPRGSCAE PTFTDTGMVA HINNSRLKAK GVGQHDNAQN
    61  FGNQSFEELR AACLRKGELF EDPLFPAEPS SLGFKDLGPN SKNVQNISWQ RPKDIINNPL
   121  FIMDGISPTD ICQGILGDCW LLAAIGSLTT CPKLLYRVVP RGQSFKKNYA GIFHFQIWQF
   181  GQWVNVVVDD RLPTKNDKLV FVHSTERSEF WSALLEKAYA KLSGSYEALS GGSTMEGLED
   241  FTGGVAQSFQ LQRPPQNLLR LLRKAVERSS LMGCSIEVTS DSELESMTDK MLVRGHAYSV
   301  TGLQDVHYRG KMETLIRVRN PWGRIEWNGA WSDSAREWEE VASDIQMQLL HKTEDGEFWM
   361  SYQDFLNNFT LLEICNLTPD TLSGDYKSYW HTTFYEGSWR RGSSAGGCRN HPGTFWTNPQ
   421  FKISLPEGDD PEDDAEGNVV VCTCLVALMQ KNWRHARQQG AQLQTIGFVL YAVPKEFQNI
   481  QDVHLKKEFF TKYQDHGFSE IFTNSREVSS QLRLPPGEYI IIPSTFEPHR DADFLLRVFT
   541  EKHSESWELD EVNYAEQLQE EKVSEDDMDQ DFLHLFKIVA GEGKEIGVYE LQRLLNRMAI
   601  KFKSFKTKGF GLDACRCMIN LMDKDGSGKL GLLEFKILWK KLKKWMDIFR ECDQDHSGTL
   661  NSYEMRLVIE KAGIKLNNKV MQVLVARYAD DDLIIDFDSF ISCFLRLKTM FTFFLTMDPK
   721  NTGHICLSLE QWLQMTMWG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAPN11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

testis: 28 nTPM
breast: 2.2 nTPM
thymus: 2 nTPM
adipose tissue: 1.5 nTPM
skin: 0.7 nTPM
blood vessel: 0.6 nTPM

Single-cell type

late primary spermatocytes: 117 nCPM
breast myoepithelial cells: 31 nCPM
early spermatids: 22 nCPM
late spermatids: 11 nCPM
early primary spermatocytes: 11 nCPM
platelets: 9.8 nCPM

Immune cell

basophil: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
total PBMC: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

cerebellum: 1.5 nTPM
cerebral cortex: 1.5 nTPM
white matter: 1.3 nTPM
hippocampal formation: 1.2 nTPM
thalamus: 1.1 nTPM
basal ganglia: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: 0.23
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAPN11 as an antibody target. Whether an autoantibody or antibody against CAPN11 could matter depends on whether native CAPN11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAPN11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CAPN11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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