Seroatlas · Human Serome Atlas

CANT1

Soluble calcium-activated nucleotidase 1

Also known as: CANT1_HUMAN, SCAN-1, SHAPY

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WVQ1
Gene
CANT1
Ensembl
ENSG00000171302
Chromosome
17
Canonical length
401 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Golgi apparatus
Quaternary structure
Homodimer

OverviewNCBI Gene

This protein encoded by this gene belongs to the apyrase family. It functions as a calcium-dependent nucleotidase with a preference for UDP. Mutations in this gene are associated with Desbuquois dysplasia with hand anomalies. Alternatively spliced transcript variants have been noted for this gene.[provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

401 residues, UniProt reviewed canonical sequence.

>Q8WVQ1|CANT1
     1  MPVQLSEHPE WNESMHSLRI SVGGLPVLAS MTKAADPRFR PRWKVILTFF VGAAILWLLC
    61  SHRPAPGRPP THNAHNWRLG QAPANWYNDT YPLSPPQRTP AGIRYRIAVI ADLDTESRAQ
   121  EENTWFSYLK KGYLTLSDSG DKVAVEWDKD HGVLESHLAE KGRGMELSDL IVFNGKLYSV
   181  DDRTGVVYQI EGSKAVPWVI LSDGDGTVEK GFKAEWLAVK DERLYVGGLG KEWTTTTGDV
   241  VNENPEWVKV VGYKGSVDHE NWVSNYNALR AAAGIQPPGY LIHESACWSD TLQRWFFLPR
   301  RASQERYSEK DDERKGANLL LSASPDFGDI AVSHVGAVVP THGFSSFKFI PNTDDQIIVA
   361  LKSEEDSGRV ASYIMAFTLD GRFLLPETKI GSVKYEGIEF I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CANT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
84 nTPM

Expression across tissuesHPA

Tissue

  • colon: 84 nTPM
  • rectum: 78 nTPM
  • prostate: 67 nTPM
  • salivary gland: 59 nTPM
  • small intestine: 52 nTPM
  • duodenum: 49 nTPM

Single-cell type

  • esophageal apical cells: 277 nCPM
  • breast lactating cells: 249 nCPM
  • goblet cells: 168 nCPM
  • colonocytes: 135 nCPM
  • syncytiotrophoblasts: 133 nCPM
  • prostatic glandular cells: 107 nCPM

Immune cell

  • neutrophil: 17 nTPM
  • eosinophil: 8.8 nTPM
  • basophil: 6.3 nTPM
  • MAIT T-cell: 5.8 nTPM
  • gdT-cell: 5.5 nTPM
  • memory CD8 T-cell: 4.8 nTPM

Brain region

  • white matter: 34 nTPM
  • medulla oblongata: 29 nTPM
  • midbrain: 28 nTPM
  • thalamus: 28 nTPM
  • hypothalamus: 27 nTPM
  • pons: 27 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CANT1.

Disease | AllUniProt

Conditions CANT1 is implicated in, by any mechanism.

Disease | GeneticClinVar

50 pathogenic / likely-pathogenic of 465 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.31
gnomAD pLI
0
gnomAD missense Z
0.49
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Apyrase
  • Apyrase superfamily
  • Apyrase

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CANT1 as an antibody target. Whether an autoantibody or antibody against CANT1 could matter depends on whether native CANT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CANT1 is annotated at the cell surface, where native CANT1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CANT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CANT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...