CAMP

Protein identityUniProt · HPA

UniProt accession

P49913

Gene

CAMP

Ensembl

ENSG00000164047

Chromosome

3

Canonical length

170 aa

Protein class

Plasma proteins, Predicted secreted proteins, Transporters

Secretome location

Secreted to blood

Quaternary structure

Homotrimer

OverviewNCBI Gene

This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. The protein plays an important role in innate immunity defense against viruses. In addition to its antibacterial, antifungal, and antiviral activities, the encoded protein functions in cell chemotaxis, immune mediator induction, and inflammatory response regulation. [provided by RefSeq, Sep 2021]

Canonical amino-acid sequenceUniProt

170 residues, UniProt reviewed canonical sequence.

>P49913|CAMP
     1  MKTQRDGHSL GRWSLVLLLL GLVMPLAIIA QVLSYKEAVL RAIDGINQRS SDANLYRLLD
    61  LDPRPTMDGD PDTPKPVSFT VKETVCPRTT QQSPEDCDFK KDGLVKRCMG TVTLNQARGS
   121  FDISCDKDNK RFALLGDFFR KSKEKIGKEF KRIVQRIKDF LRNLVPRTES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAMP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.43

Highest tissue expression

2,752 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CAMP.

Disease | ImmuneIEDB

Conditions an epitope on CAMP was assayed in.

• psoriasis T cell
• autoimmune atherosclerosis T cell
• coronary artery disease T cell
• systemic scleroderma T cell
• atopic dermatitis T cell

Disease | AutoantibodyPubMed

Conditions in which antibodies against CAMP are reported. Each links to that disease's full target list.

• Psoriasis 5
• Lupus Erythematosus, Systemic 3

ReferencesPubMed · IEDB

Publications for CAMP from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.55

gnomAD pLI

0

gnomAD missense Z

0.16

DepMap mean gene effect

-0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• amyloid fibril formation
• antibacterial humoral response
• antimicrobial humoral immune response mediated by antimicrobial peptide
• cellular response to butyrate
• cellular response to exogenous dsRNA
• cellular response to interleukin-1
• cellular response to interleukin-6
• cellular response to lipopolysaccharide
• cellular response to peptidoglycan
• cellular response to tumor necrosis factor
• cytolysis
• defense response to bacterium
• defense response to Gram-negative bacterium
• defense response to Gram-positive bacterium
• dentinogenesis
• innate immune response
• innate immune response in mucosa
• killing by host of symbiont cells
• leukotriene biosynthetic process
• negative regulation of apoptotic process
• neutrophil activation
• positive regulation of angiogenesis
• positive regulation of antimicrobial humoral response
• positive regulation of cell population proliferation
• positive regulation of granulocyte macrophage colony-stimulating factor production
• positive regulation of insulin secretion involved in cellular response to glucose stimulus
• positive regulation of interleukin-1 beta production
• positive regulation of macrophage inflammatory protein 1 alpha production
• positive regulation of monocyte chemotactic protein-1 production
• positive regulation of tumor necrosis factor production
• response to glucose
• prostaglandin production involved in inflammatory response

Molecular functions

• lipopolysaccharide binding

Cellular components

• cell projection
• extracellular exosome
• extracellular region
• extracellular space
• specific granule
• specific granule lumen
• tertiary granule lumen

Protein domainsUniProt · Pfam · InterPro

• Cystatin superfamily
• Cathelicidin
• Cathelicidin-like
• Cathelicidin, conserved site
• Cathelicidin, antimicrobial peptide, C-terminal
• LPS binding domain of CAP18 (C terminal)

KeywordsUniProt

• Antibiotic
• Antimicrobial
• Cleavage on pair of basic residues
• Disulfide bond
• Immunity
• Innate immunity
• Pharmaceutical
• Secreted
• Signal