Seroatlas · Human Serome Atlas

CAMKMT

Calmodulin-lysine N-methyltransferase

Also known as: C2orf34, CLNMT, CMKMT_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z624
Gene
CAMKMT
Ensembl
ENSG00000143919
Chromosome
2
Canonical length
323 aa
Protein class
Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes a class I protein methyltransferase that acts in the formation of trimethyllysine in calmodulin. The protein contains a AdoMet-binding motif and may play a role in calcium-dependent signaling. [provided by RefSeq, Sep 2012]

Canonical amino-acid sequenceUniProt

323 residues, UniProt reviewed canonical sequence.

>Q7Z624|CAMKMT
     1  MESRVADAGT GETARAAGGS PAVGCTTRGP VVSAPLGAAR WKLLRQVLKQ KHLDDCLRHV
    61  SVRRFESFNL FSVTEGKERE TEEEVGAWVQ YTSIFCPEYS ISLRHNSGSL NVEDVLTSFD
   121  NTGNVCIWPS EEVLAYYCLK HNNIFRALAV CELGGGMTCL AGLMVAISAD VKEVLLTDGN
   181  EKAIRNVQDI ITRNQKAGVF KTQKISSCVL RWDNETDVSQ LEGHFDIVMC ADCLFLDQYR
   241  ASLVDAIKRL LQPRGKAMVF APRRGNTLNQ FCNLAEKAGF CIQRHENYDE HISNFHSKLK
   301  KENPDIYEEN LHYPLLLILT KHG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAMKMT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 14 nTPM
  • testis: 12 nTPM
  • cerebral cortex: 11 nTPM
  • hypothalamus: 9.4 nTPM
  • amygdala: 9.2 nTPM
  • pancreas: 9.2 nTPM

Single-cell type

  • myonuclei: 598 nCPM
  • choroid plexus epithelial cells: 531 nCPM
  • retinal ganglion cells: 514 nCPM
  • distal convoluted tubule cells: 485 nCPM
  • neutrophil progenitors: 442 nCPM
  • loop of henle epithelial cells: 426 nCPM

Immune cell

  • memory B-cell: 21 nTPM
  • T-reg: 18 nTPM
  • naive CD4 T-cell: 17 nTPM
  • naive B-cell: 15 nTPM
  • naive CD8 T-cell: 13 nTPM
  • basophil: 13 nTPM

Brain region

  • basal ganglia: 30 nTPM
  • cerebellum: 27 nTPM
  • white matter: 26 nTPM
  • hypothalamus: 24 nTPM
  • choroid plexus: 24 nTPM
  • thalamus: 23 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CAMKMT.

Disease | AllUniProt

Conditions CAMKMT is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.52
gnomAD pLI
0
gnomAD missense Z
-0.14
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CAMKMT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

  • HSP90

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAMKMT as an antibody target. Whether an autoantibody or antibody against CAMKMT could matter depends on whether native CAMKMT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAMKMT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CAMKMT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CAMKMT. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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