Seroatlas · Human Serome Atlas

CALHM6

Calcium homeostasis modulator protein 6

Also known as: C6orf187, CAHM6_HUMAN, dJ93H18.5, FAM26F, INAM, OTTHUMP00000017061, OTTHUMP00000017062, RP1-93H18.5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5R3K3
Gene: CALHM6
Ensembl: ENSG00000188820
Chromosome: 6
Canonical length: 315 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable monoatomic cation channel activity. Predicted to be involved in ATP export; monoatomic cation transmembrane transport; and regulation of natural killer cell cytokine production. Predicted to be located in immunological synapse. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>Q5R3K3|CALHM6
     1  MEKFRAVLDL HVKHHSALGY GLVTLLTAGG ERIFSAVAFQ CPCSAAWNLP YGLVFLLVPA
    61  LALFLLGYVL SARTWRLLTG CCSSARASCG SALRGSLVCT QISAAAALAP LTWVAVALLG
   121  GAFYECAATG SAAFAQRLCL GRNRSCAAEL PLVPCNQAKA SDVQDLLKDL KAQSQVLGWI
   181  LIAVVIIILL IFTSVTRCLS PVSFLQLKFW KIYLEQEQQI LKSKATEHAT ELAKENIKCF
   241  FEGSHPKEYN TPSMKEWQQI SSLYTFNPKG QYYSMLHKYV NRKEKTHSIR STEGDTVIPV
   301  LGFVDSSGIN STPEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CALHM6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 130 nTPM

Expression across tissuesHPA

Tissue

spleen: 130 nTPM
lymph node: 68 nTPM
appendix: 57 nTPM
bone marrow: 39 nTPM
liver: 23 nTPM
tonsil: 22 nTPM

Single-cell type

kupffer cells: 369 nCPM
hofbauer cells: 80 nCPM
macrophages: 68 nCPM
cdc: 58 nCPM
monocytes: 57 nCPM
b-cells: 27 nCPM

Immune cell

non-classical monocyte: 866 nTPM
intermediate monocyte: 726 nTPM
naive B-cell: 310 nTPM
memory B-cell: 233 nTPM
classical monocyte: 206 nTPM
myeloid DC: 194 nTPM

Brain region

medulla oblongata: 7.9 nTPM
spinal cord: 2.9 nTPM
white matter: 2.5 nTPM
hypothalamus: 2.4 nTPM
pons: 2.4 nTPM
basal ganglia: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.77
gnomAD pLI: 0.01
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

ATP export
regulation of natural killer cell cytokine production

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CALHM6 as an antibody target. Whether an autoantibody or antibody against CALHM6 could matter depends on whether native CALHM6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CALHM6 is annotated at the cell surface, where native CALHM6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CALHM6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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