Seroatlas · Human Serome Atlas

CALHM5

Calcium homeostasis modulator protein 5

Also known as: C6orf188, CAHM5_HUMAN, dJ493F7.3, FAM26E, MGC45451

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N5C1
Gene: CALHM5
Ensembl: ENSG00000178033
Chromosome: 6
Canonical length: 309 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to enable monoatomic cation channel activity. Predicted to be involved in ATP export and monoatomic cation transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>Q8N5C1|CALHM5
     1  MDAFQGILKF FLNQKTVIGY SFMALLTVGS ERLFSVVAFK CPCSTENMTY GLVFLFAPAW
    61  VLLILGFFLN NRSWRLFTGC CVNPRKIFPR GHSCRFFYVL GQITLSSLVA PVMWLSVALL
   121  NGTFYECAMS GTRSSGLLEL ICKGKPKECW EELHKVSCGK TSMLPTVNEE LKLSLQAQSQ
   181  ILGWCLICSA SFFSLLTTCY ARCRSKVSYL QLSFWKTYAQ KEKEQLENTF LDYANKLSER
   241  NLKCFFENKR PDPFPMPTFA AWEAASELHS FHQSQQHYST LHRVVDNGLQ LSPEDDETTM
   301  VLVGTAHNM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CALHM5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 7.5 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 7.5 nTPM
placenta: 4.1 nTPM
adipose tissue: 3.1 nTPM
tongue: 2.4 nTPM
heart muscle: 2.2 nTPM
smooth muscle: 2 nTPM

Single-cell type

platelets: 30 nCPM
podocytes: 23 nCPM
pericytes: 11 nCPM
vascular smooth muscle cells: 7.3 nCPM
hepatic stellate cells: 6.5 nCPM
kupffer cells: 6.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 2.5 nTPM
cerebral cortex: 2.4 nTPM
choroid plexus: 2.4 nTPM
thalamus: 2.4 nTPM
amygdala: 2.3 nTPM
cerebellum: 2.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
DepMap mean gene effect: 0.18
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CALHM5 as an antibody target. Whether an autoantibody or antibody against CALHM5 could matter depends on whether native CALHM5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CALHM5 is annotated at the cell surface, where native CALHM5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CALHM5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...