Seroatlas · Human Serome Atlas

CALHM3

Calcium homeostasis modulator protein 3

Also known as: bA225H22.7, CAHM3_HUMAN, FAM26A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86XJ0
Gene: CALHM3
Ensembl: ENSG00000183128
Chromosome: 10
Canonical length: 344 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable monoatomic cation channel activity and voltage-gated monoatomic ion channel activity. Predicted to be involved in ATP transport; protein heterooligomerization; and sensory perception of taste. Predicted to be located in basolateral plasma membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

344 residues, UniProt reviewed canonical sequence.

>Q86XJ0|CALHM3
     1  MDKFRMLFQH FQSSSESVMN GICLLLAAVT VKLYSSFDFN CPCLVHYNAL YGLGLLLTPP
    61  LALFLCGLLA NRQSVVMVEE WRRPAGHRRK DPGIIRYMCS SVLQRALAAP LVWILLALLD
   121  GKCFVCAFSS SVDPEKFLDF ANMTPSQVQL FLAKVPCKED ELVRDSPARK AVSRYLRCLS
   181  QAIGWSVTLL LIIAAFLARC LRPCFDQTVF LQRRYWSNYV DLEQKLFDET CCEHARDFAH
   241  RCVLHFFASM RSELQARGLR RGNAGRRLEL PAVPEPPEGL DSGSGKAHLR AISSREQVDR
   301  LLSTWYSSKP PLDLAASPGL CGGGLSHRAP TLALGTRLSQ HTDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CALHM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 0.4 nTPM

Expression across tissuesHPA

Tissue

pancreas: 0.4 nTPM
testis: 0.4 nTPM
hypothalamus: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
cerebral cortex: 0.1 nTPM

Single-cell type

extravillous trophoblasts: 11 nCPM
late spermatids: 5.3 nCPM
early spermatids: 4.8 nCPM
syncytiotrophoblasts: 1.6 nCPM
gastric progenitor cells: 1.3 nCPM
epididymal principal cells: 1.1 nCPM

Immune cell

intermediate monocyte: 0.3 nTPM
myeloid DC: 0.2 nTPM
classical monocyte: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM

Brain region

hypothalamus: 0.5 nTPM
basal ganglia: 0.2 nTPM
cerebral cortex: 0.2 nTPM
hippocampal formation: 0.2 nTPM
white matter: 0.2 nTPM
amygdala: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0
gnomAD missense Z: 0.35
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CALHM3 as an antibody target. Whether an autoantibody or antibody against CALHM3 could matter depends on whether native CALHM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CALHM3 is annotated at the cell surface, where native CALHM3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CALHM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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