Seroatlas · Human Serome Atlas

CALHM2

Calcium homeostasis modulator protein 2

Also known as: CAHM2_HUMAN, FAM26B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HA72
Gene: CALHM2
Ensembl: ENSG00000138172
Chromosome: 10
Canonical length: 323 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Mitochondria,Cytosol

OverviewNCBI Gene

Predicted to enable monoatomic cation channel activity. Involved in ATP export and positive regulation of apoptotic process. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

323 residues, UniProt reviewed canonical sequence.

>Q9HA72|CALHM2
     1  MAALIAENFR FLSLFFKSKD VMIFNGLVAL GTVGSQELFS VVAFHCPCSP ARNYLYGLAA
    61  IGVPALVLFI IGIILNNHTW NLVAECQHRR TKNCSAAPTF LLLSSILGRA AVAPVTWSVI
   121  SLLRGEAYVC ALSEFVDPSS LTAREEHFPS AHATEILARF PCKENPDNLS DFREEVSRRL
   181  RYESQLFGWL LIGVVAILVF LTKCLKHYCS PLSYRQEAYW AQYRANEDQL FQRTAEVHSR
   241  VLAANNVRRF FGFVALNKDD EELIANFPVE GTQPRPQWNA ITGVYLYREN QGLPLYSRLH
   301  KWAQGLAGNG AAPDNVEMAL LPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CALHM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 54 nTPM

Expression across tissuesHPA

Tissue

endometrium: 54 nTPM
cervix: 48 nTPM
adipose tissue: 48 nTPM
ovary: 46 nTPM
blood vessel: 44 nTPM
fallopian tube: 41 nTPM

Single-cell type

decidual stromal cells: 106 nCPM
extravillous trophoblasts: 105 nCPM
hofbauer cells: 67 nCPM
vascular smooth muscle cells: 42 nCPM
fibroblasts: 38 nCPM
ovarian stromal cells: 37 nCPM

Immune cell

non-classical monocyte: 216 nTPM
intermediate monocyte: 178 nTPM
myeloid DC: 152 nTPM
classical monocyte: 92 nTPM
total PBMC: 86 nTPM
gdT-cell: 84 nTPM

Brain region

thalamus: 11 nTPM
medulla oblongata: 10 nTPM
white matter: 10 nTPM
spinal cord: 9.7 nTPM
pons: 9.5 nTPM
cerebral cortex: 8.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.64
gnomAD pLI: 0
gnomAD missense Z: -0.11
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

monoatomic cation channel activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CALHM2 as an antibody target. Whether an autoantibody or antibody against CALHM2 could matter depends on whether native CALHM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CALHM2 is annotated at the cell surface, where native CALHM2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CALHM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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