Seroatlas · Human Serome Atlas

CALHM1

Calcium homeostasis modulator protein 1

Also known as: CAHM1_HUMAN, FAM26C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IU99
Gene: CALHM1
Ensembl: ENSG00000185933
Chromosome: 10
Canonical length: 346 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.[provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>Q8IU99|CALHM1
     1  MMDKFRMIFQ FLQSNQESFM NGICGIMALA SAQMYSAFDF NCPCLPGYNA AYSAGILLAP
    61  PLVLFLLGLV MNNNVSMLAE EWKRPLGRRA KDPAVLRYMF CSMAQRALIA PVVWVAVTLL
   121  DGKCFLCAFC TAVPVSALGN GSLAPGLPAP ELARLLARVP CPEIYDGDWL LAREVAVRYL
   181  RCISQALGWS FVLLTTLLAF VVRSVRPCFT QAAFLKSKYW SHYIDIERKL FDETCTEHAK
   241  AFAKVCIQQF FEAMNHDLEL GHTHGTLATA PASAAAPTTP DGAEEEREKL RGITDQGTMN
   301  RLLTSWHKCK PPLRLGQEEP PLMGNGWAGG GPRPPRKEVA TYFSKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CALHM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 1.9 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 1.9 nTPM
cerebellum: 1 nTPM
hypothalamus: 0.8 nTPM
kidney: 0.7 nTPM
amygdala: 0.4 nTPM
hippocampal formation: 0.4 nTPM

Single-cell type

brain excitatory neurons: 1.6 nCPM
other brain neurons: 1.4 nCPM
corticotrophs: 0.8 nCPM
brain inhibitory neurons: 0.3 nCPM
endometrial secretory cells: 0.3 nCPM
plasma cells: 0.3 nCPM

Immune cell

non-classical monocyte: 0.3 nTPM
intermediate monocyte: 0.2 nTPM
myeloid DC: 0.2 nTPM
gdT-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
NK-cell: 0.1 nTPM

Brain region

pons: 5.2 nTPM
hypothalamus: 3.5 nTPM
cerebellum: 3.1 nTPM
cerebral cortex: 3 nTPM
medulla oblongata: 2.8 nTPM
midbrain: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0
gnomAD missense Z: -0.17
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CALHM1 as an antibody target. Whether an autoantibody or antibody against CALHM1 could matter depends on whether native CALHM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CALHM1 is annotated at the cell surface, where native CALHM1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CALHM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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