Seroatlas · Human Serome Atlas

CALCB

Calcitonin gene-related peptide 2

Also known as: CALC2, CALCB_HUMAN, CGRP-II, FLJ30166

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P10092
Gene: CALCB
Ensembl: ENSG00000175868
Chromosome: 11
Canonical length: 127 aa
Protein class: FDA approved drug targets, Plasma proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

Enables hormone activity. Involved in calcitonin gene-related peptide receptor signaling pathway. Is active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

127 residues, UniProt reviewed canonical sequence.

>P10092|CALCB
     1  MGFRKFSPFL ALSILVLYQA GSLQAAPFRS ALESSPDPAT LSKEDARLLL AALVQDYVQM
    61  KASELKQEQE TQGSSSAAQK RACNTATCVT HRLAGLLSRS GGMVKSNFVP TNVGSKAFGR
   121  RRRDLQA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CALCB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 19 nTPM
hypothalamus: 8.7 nTPM
spinal cord: 2.3 nTPM
pituitary gland: 2.2 nTPM
pancreas: 1.5 nTPM
colon: 1.4 nTPM

Single-cell type

renal collecting duct intercalated cells: 68 nCPM
epicardial cells: 61 nCPM
pancreatic acinar cells: 59 nCPM
proximal tubule cells: 54 nCPM
salivary acinar cells: 32 nCPM
pancreatic islet cells: 27 nCPM

Immune cell

NK-cell: 0.3 nTPM
eosinophil: 0.2 nTPM
gdT-cell: 0.1 nTPM
MAIT T-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM

Brain region

pons: 42 nTPM
midbrain: 27 nTPM
medulla oblongata: 22 nTPM
hypothalamus: 17 nTPM
white matter: 12 nTPM
spinal cord: 7.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0.1
gnomAD missense Z: -0.06
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CALCB as an antibody target. Whether an autoantibody or antibody against CALCB could matter depends on whether native CALCB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CALCB is annotated as secreted, so native CALCB circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CALCB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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