Seroatlas · Human Serome Atlas

CALCA

Calcitonin

Also known as: CALC_HUMAN, CALC1, CGRP, CGRP-alpha

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P01258
Gene: CALCA
Ensembl: ENSG00000110680
Chromosome: 11
Canonical length: 141 aa
Protein class: Cancer-related genes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins, Transporters
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]

Canonical amino-acid sequenceUniProt

141 residues, UniProt reviewed canonical sequence.

>P01258|CALCA
     1  MGFQKFSPFL ALSILVLLQA GSLHAAPFRS ALESSPADPA TLSEDEARLL LAALVQDYVQ
    61  MKASELEQEQ EREGSSLDSP RSKRCGNLST CMLGTYTQDF NKFHTFPQTA IGVGAPGKKR
   121  DMSSDLERDH RPHVSMPQNA N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CALCA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 167 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 167 nTPM
thyroid gland: 146 nTPM
kidney: 37 nTPM
liver: 30 nTPM
urinary bladder: 3.8 nTPM
spleen: 3.1 nTPM

Single-cell type

renal collecting duct intercalated cells: 49 nCPM
pancreatic islet cells: 46 nCPM
vascular smooth muscle cells: 17 nCPM
epicardial cells: 6.8 nCPM
hepatocytes: 4.7 nCPM
pancreatic acinar cells: 4.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 79 nTPM
medulla oblongata: 52 nTPM
white matter: 30 nTPM
midbrain: 17 nTPM
spinal cord: 4.2 nTPM
hypothalamus: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.6
gnomAD pLI: 0.02
gnomAD missense Z: -0.6
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CALCA as an antibody target. Whether an autoantibody or antibody against CALCA could matter depends on whether native CALCA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CALCA is annotated as secreted, so native CALCA circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CALCA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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