Seroatlas · Human Serome Atlas

CALB2

Calretinin

Also known as: CAL2, CALB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P22676
Gene: CALB2
Ensembl: ENSG00000172137
Chromosome: 16
Canonical length: 271 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>P22676|CALB2
     1  MAGPQQQPPY LHLAELTASQ FLEIWKHFDA DGNGYIEGKE LENFFQELEK ARKGSGMMSK
    61  SDNFGEKMKE FMQKYDKNSD GKIEMAELAQ ILPTEENFLL CFRQHVGSSA EFMEAWRKYD
   121  TDRSGYIEAN ELKGFLSDLL KKANRPYDEP KLQEYTQTIL RMFDLNGDGK LGLSEMSRLL
   181  PVQENFLLKF QGMKLTSEEF NAIFTFYDKD RSGYIDEHEL DALLKDLYEK NKKEMNIQQL
   241  TNYRKSVMSL AEAGKLYRKD LEIVLCSEPP M

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CALB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 305 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 305 nTPM
cerebellum: 141 nTPM
adipose tissue: 96 nTPM
midbrain: 57 nTPM
breast: 54 nTPM
cerebral cortex: 48 nTPM

Single-cell type

other brain neurons: 114 nCPM
mesothelial cells: 55 nCPM
mast cells: 51 nCPM
brain excitatory neurons: 45 nCPM
brain inhibitory neurons: 43 nCPM
breast lactating cells: 24 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 275 nTPM
pons: 179 nTPM
hypothalamus: 161 nTPM
medulla oblongata: 119 nTPM
midbrain: 83 nTPM
cerebral cortex: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
gnomAD missense Z: 0.2
DepMap mean gene effect: 0.2
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CALB2 as an antibody target. Whether an autoantibody or antibody against CALB2 could matter depends on whether native CALB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CALB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CALB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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