Seroatlas · Human Serome Atlas

CAGE1

Cancer-associated gene 1 protein

Also known as: bA69L16.7, CAGE1_HUMAN, CT95, CTAG3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TC20
Gene
CAGE1
Ensembl
ENSG00000164304
Chromosome
6
Canonical length
777 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CAGE1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

777 residues, UniProt reviewed canonical sequence.

>Q8TC20|CAGE1
     1  MNKDYQKFWS SPSDPVHFEV DTSHEKVESM SESDTMNVSN LSQGVMLSHS PICMETTGTT
    61  CDLPQNEIKN FERENEYEST LCEDAYGTLD NLLNDNNIEN YSTNALIQPV DTISISSLRQ
   121  FETVCKFHWV EAFDDEMTEK PEFQSQVYNY AKDNNIKQDS FKEENPMETS VSANTDQLGN
   181  EYFRQPPPRS PPLIHCSGEM LKFTEKSLAK SIAKESALNP SQPPSFLCKT AVPSKEIQNY
   241  GEIPEMSVSY EKEVTAEGVE RPEIVSTWSS AGISWRSEAC RENCEMPDWE QSAESLQPVQ
   301  EDMALNEVLQ KLKHTNRKQE VRIQELQCSN LYLEKRVKEL QMKITKQQVF IDVINKLKEN
   361  VEELIEDKYK IILEKNDTKK TLQNLEEVLA NTQKHLQESR NDKEMLQLQF KKIKANYVCL
   421  QERYMTEMQQ KNKSVSQYLE MDKTLSKKEE EVERLQQLKK ELEKATASAL DLLKREKEAQ
   481  EQEFLSLQEE FQKLEKENLE ERQKLKSRLE KLLTQVRNLQ FMSENERTKN IKLQQQINEV
   541  KNENAKLKQQ VARSEEQNYV PKFETAQLKD QLEEVLKSDI TKDTKTTHSN LLPDCSPCEE
   601  RLNPADIKRA SQLASKMHSL LALMVGLLTC QDIINSDAEH FKESEKVSDI MLQKLKSLHL
   661  KKKTLDKEVI DCDSDEAKSI RDVPTLLGAK LDKYHSLNEE LDFLVTSYEE IIECADQRLA
   721  ISHSQIAHLE ERNKHLEDLI RKPREKARKP RSKSLENHPK SMTMMPALFK ENRNDLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAGE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
4.7 nTPM

Expression across tissuesHPA

Tissue

  • testis: 4.7 nTPM
  • bone marrow: 0.2 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • early spermatids: 142 nCPM
  • late primary spermatocytes: 126 nCPM
  • late spermatids: 83 nCPM
  • epicardial cells: 30 nCPM
  • pdcs: 28 nCPM
  • innate lymphoid cells: 11 nCPM

Immune cell

  • basophil: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • neutrophil: 0.1 nTPM
  • plasmacytoid DC: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • choroid plexus: 0.7 nTPM
  • basal ganglia: 0.5 nTPM
  • cerebellum: 0.5 nTPM
  • cerebral cortex: 0.5 nTPM
  • pons: 0.5 nTPM
  • white matter: 0.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CAGE1.

Disease | ImmuneIEDB

Conditions an epitope on CAGE1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.98
gnomAD pLI
0
gnomAD missense Z
0.89
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Cancer-associated gene protein 1, N-terminal
  • Cancer-associated gene 1 homolog
  • Cancer-associated gene protein 1 family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAGE1 as an antibody target. Whether an autoantibody or antibody against CAGE1 could matter depends on whether native CAGE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAGE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CAGE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CAGE1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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