Seroatlas · Human Serome Atlas

CADM4

Cell adhesion molecule 4

Also known as: CADM4_HUMAN, IGSF4C, Necl-4, SynCAM4, TSLL2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NFZ8
Gene: CADM4
Ensembl: ENSG00000105767
Chromosome: 19
Canonical length: 388 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables vascular endothelial growth factor receptor 2 binding activity. Involved in several processes, including negative regulation of protein phosphorylation; regulation of Rac protein signal transduction; and regulation of wound healing. Located in cell leading edge and cell-cell contact zone. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

388 residues, UniProt reviewed canonical sequence.

>Q8NFZ8|CADM4
     1  MGRARRFQWP LLLLWAAAAG PGAGQEVQTE NVTVAEGGVA EITCRLHQYD GSIVVIQNPA
    61  RQTLFFNGTR ALKDERFQLE EFSPRRVRIR LSDARLEDEG GYFCQLYTED THHQIATLTV
   121  LVAPENPVVE VREQAVEGGE VELSCLVPRS RPAATLRWYR DRKELKGVSS SQENGKVWSV
   181  ASTVRFRVDR KDDGGIIICE AQNQALPSGH SKQTQYVLDV QYSPTARIHA SQAVVREGDT
   241  LVLTCAVTGN PRPNQIRWNR GNESLPERAE AVGETLTLPG LVSADNGTYT CEASNKHGHA
   301  RALYVLVVYD PGAVVEAQTS VPYAIVGGIL ALLVFLIICV LVGMVWCSVR QKGSYLTHEA
   361  SGLDEQGEAR EAFLNGSDGH KRKEEFFI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CADM4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 203 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 203 nTPM
midbrain: 157 nTPM
basal ganglia: 128 nTPM
hippocampal formation: 126 nTPM
amygdala: 120 nTPM
hypothalamus: 108 nTPM

Single-cell type

schwann cells: 99 nCPM
oligodendrocytes: 95 nCPM
oligodendrocyte progenitor cells: 86 nCPM
late spermatids: 61 nCPM
bergmann glia: 52 nCPM
breast myoepithelial cells: 35 nCPM

Immune cell

plasmacytoid DC: 1.5 nTPM
eosinophil: 0.2 nTPM
neutrophil: 0.2 nTPM
intermediate monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

white matter: 221 nTPM
cerebellum: 191 nTPM
thalamus: 188 nTPM
basal ganglia: 187 nTPM
midbrain: 186 nTPM
medulla oblongata: 175 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 2.74
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CADM4 as an antibody target. Whether an autoantibody or antibody against CADM4 could matter depends on whether native CADM4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CADM4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CADM4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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