Seroatlas · Human Serome Atlas

CADM2

Cell adhesion molecule 2

Also known as: CADM2_HUMAN, IGSF4D, Necl-3, NECL3, SynCAM2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N3J6
Gene: CADM2
Ensembl: ENSG00000175161
Chromosome: 3
Canonical length: 435 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

435 residues, UniProt reviewed canonical sequence.

>Q8N3J6|CADM2
     1  MIWKRSAVLR FYSVCGLLLQ GSQGQFPLTQ NVTVVEGGTA ILTCRVDQND NTSLQWSNPA
    61  QQTLYFDDKK ALRDNRIELV RASWHELSIS VSDVSLSDEG QYTCSLFTMP VKTSKAYLTV
   121  LGVPEKPQIS GFSSPVMEGD LMQLTCKTSG SKPAADIRWF KNDKEIKDVK YLKEEDANRK
   181  TFTVSSTLDF RVDRSDDGVA VICRVDHESL NATPQVAMQV LEIHYTPSVK IIPSTPFPQE
   241  GQPLILTCES KGKPLPEPVL WTKDGGELPD PDRMVVSGRE LNILFLNKTD NGTYRCEATN
   301  TIGQSSAEYV LIVHDVPNTL LPTTIIPSLT TATVTTTVAI TTSPTTSATT SSIRDPNALA
   361  GQNGPDHALI GGIVAVVVFV TLCSIFLLGR YLARHKGTYL TNEAKGAEDA PDADTAIINA
   421  EGSQVNAEEK KEYFI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CADM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 88 nTPM

Expression across tissuesHPA

Tissue

retina: 88 nTPM
cerebral cortex: 49 nTPM
amygdala: 18 nTPM
basal ganglia: 18 nTPM
hippocampal formation: 18 nTPM
midbrain: 17 nTPM

Single-cell type

rod photoreceptor cells: 8,749 nCPM
oligodendrocytes: 6,103 nCPM
cone photoreceptor cells: 5,550 nCPM
oligodendrocyte progenitor cells: 4,761 nCPM
corticotrophs: 4,599 nCPM
brain excitatory neurons: 4,499 nCPM

Immune cell

basophil: 6 nTPM
memory B-cell: 1 nTPM
MAIT T-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 150 nTPM
thalamus: 108 nTPM
hippocampal formation: 108 nTPM
basal ganglia: 106 nTPM
midbrain: 101 nTPM
pons: 98 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.89
gnomAD missense Z: 1.98
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

homophilic cell adhesion via plasma membrane adhesion molecules

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CADM2 as an antibody target. Whether an autoantibody or antibody against CADM2 could matter depends on whether native CADM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CADM2 is annotated at the cell surface, where native CADM2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CADM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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