Seroatlas · Human Serome Atlas

CADM1

Cell adhesion molecule 1

Also known as: BL2, CADM1_HUMAN, IGSF4, IGSF4A, Necl-2, NECL2, RA175, ST17, SYNCAM, SYNCAM1, TSLC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BY67
Gene
CADM1
Ensembl
ENSG00000182985
Chromosome
11
Canonical length
442 aa
Protein class
Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables signaling receptor binding activity. Involved in several processes, including cell recognition; positive regulation of cytokine production; and susceptibility to natural killer cell mediated cytotoxicity. Located in plasma membrane. Implicated in breast carcinoma and prostate cancer. Biomarker of cervix uteri carcinoma in situ. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

442 residues, UniProt reviewed canonical sequence.

>Q9BY67|CADM1
     1  MASVVLPSGS QCAAAAAAAA PPGLRLRLLL LLFSAAALIP TGDGQNLFTK DVTVIEGEVA
    61  TISCQVNKSD DSVIQLLNPN RQTIYFRDFR PLKDSRFQLL NFSSSELKVS LTNVSISDEG
   121  RYFCQLYTDP PQESYTTITV LVPPRNLMID IQKDTAVEGE EIEVNCTAMA SKPATTIRWF
   181  KGNTELKGKS EVEEWSDMYT VTSQLMLKVH KEDDGVPVIC QVEHPAVTGN LQTQRYLEVQ
   241  YKPQVHIQMT YPLQGLTREG DALELTCEAI GKPQPVMVTW VRVDDEMPQH AVLSGPNLFI
   301  NNLNKTDNGT YRCEASNIVG KAHSDYMLYV YDPPTTIPPP TTTTTTTTTT TTTILTIITD
   361  SRAGEEGSIR AVDHAVIGGV VAVVVFAMLC LLIILGRYFA RHKGTYFTHE AKGADDAADA
   421  DTAIINAEGG QNNSEEKKEY FI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CADM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
267 nTPM

Expression across tissuesHPA

Tissue

  • retina: 267 nTPM
  • epididymis: 98 nTPM
  • cerebellum: 70 nTPM
  • lung: 68 nTPM
  • thyroid gland: 65 nTPM
  • liver: 61 nTPM

Single-cell type

  • rod photoreceptor cells: 4,759 nCPM
  • retinal bipolar cells: 2,456 nCPM
  • sertoli cells: 2,067 nCPM
  • astrocytes: 1,469 nCPM
  • cone photoreceptor cells: 1,410 nCPM
  • müller glia: 1,212 nCPM

Immune cell

  • myeloid DC: 8.1 nTPM
  • gdT-cell: 8 nTPM
  • T-reg: 4.7 nTPM
  • MAIT T-cell: 3.4 nTPM
  • memory CD4 T-cell: 2.9 nTPM
  • memory CD8 T-cell: 2.1 nTPM

Brain region

  • cerebellum: 176 nTPM
  • basal ganglia: 134 nTPM
  • hypothalamus: 132 nTPM
  • cerebral cortex: 120 nTPM
  • amygdala: 109 nTPM
  • pons: 105 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CADM1.

Disease | ImmuneIEDB

Conditions an epitope on CADM1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.66
gnomAD missense Z
1.84
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CADM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CADM1 as an antibody target. Whether an autoantibody or antibody against CADM1 could matter depends on whether native CADM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CADM1 is annotated at the cell surface, where native CADM1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CADM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CADM1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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