Seroatlas · Human Serome Atlas

CACTIN-AS1

Putative uncharacterized protein encoded by CACTIN-AS1

Also known as: CAAS1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N1I8
Gene: CACTIN-AS1
Canonical length: 211 aa

OverviewNCBI Gene

No narrative summary is available for CACTIN-AS1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

211 residues, UniProt reviewed canonical sequence.

>Q8N1I8|CACTIN-AS1
     1  MRPEVGREPA ALQPRQRPRS DHQLHRSPFT VPPRTPACRS PGPSPPIAVA LEVKPQLEDA
    61  IGKLAAEAVA VRVFPLAVDD LESDVLVGRP RVEAQDGEIL VVGAGLQEVL GRGALVDEVG
   121  VEDVELVSLH DLGRWVVKVV VRLVVLVPLE ARVHAVEEAR LAWPVLVGPQ DGGCPGSART
   181  AAGKSFHHLW PQGQWASKPR MNEGTPQCAC R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CACTIN-AS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.73

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CACTIN-AS1 as an antibody target. Whether an autoantibody or antibody against CACTIN-AS1 could matter depends on whether native CACTIN-AS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CACTIN-AS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CACTIN-AS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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