CACFD1
Calcium channel flower homolog
Also known as: C9orf7, D9S2135, flower, FLOWR_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UGQ2
- Gene
- CACFD1
- Ensembl
- ENSG00000160325
- Chromosome
- 9
- Canonical length
- 172 aa
- Protein class
- Predicted membrane proteins, Transporters
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Predicted to be involved in vesicle-mediated transport. Predicted to be located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
172 residues, UniProt reviewed canonical sequence.
>Q9UGQ2|CACFD1
1 MSSSGGAPGA SASSAPPAQE EGMTWWYRWL CRLSGVLGAV SCAISGLFNC ITIHPLNIAA
61 GVWMIMNAFI LLLCEAPFCC QFIEFANTVA EKVDRLRSWQ KAVFYCGMAV VPIVISLTLT
121 TLLGNAIAFA TGVLYGLSAL GKKGDAISYA RIQQQRQQAD EEKLAETLEG ELLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CACFD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.43
- Highest tissue expression
- 57 nTPM
Expression across tissuesHPA
Tissue
- liver: 57 nTPM
- kidney: 28 nTPM
- stomach: 27 nTPM
- testis: 23 nTPM
- colon: 19 nTPM
- pituitary gland: 18 nTPM
Single-cell type
- proximal tubule cells: 12 nCPM
- renal connecting tubule cells: 9.4 nCPM
- oligodendrocyte progenitor cells: 8.7 nCPM
- loop of henle epithelial cells: 8.6 nCPM
- papillary tip epithelial cells: 8.6 nCPM
- astrocytes: 7.9 nCPM
Immune cell
- basophil: 3.8 nTPM
- memory B-cell: 2 nTPM
- eosinophil: 1.6 nTPM
- naive B-cell: 0.7 nTPM
- NK-cell: 0.6 nTPM
- classical monocyte: 0.5 nTPM
Brain region
- cerebellum: 15 nTPM
- white matter: 13 nTPM
- medulla oblongata: 13 nTPM
- cerebral cortex: 12 nTPM
- choroid plexus: 12 nTPM
- thalamus: 11 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.24
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.15
- DepMap mean gene effect
- 0.08
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- TVP18/Calcium channel flower
- Uncharacterized conserved protein CG6151-P
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CACFD1 as an antibody target. Whether an autoantibody or antibody against CACFD1 could matter depends on whether native CACFD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CACFD1 is annotated at the cell surface, where native CACFD1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label CACFD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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