Seroatlas · Human Serome Atlas

CABCOCO1

Ciliary-associated calcium-binding coiled-coil protein 1

Also known as: bA63A2.1, C10orf107, CBCO1_HUMAN, Em:AC022398.2, MGC44593

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IVU9
Gene: CABCOCO1
Ensembl: ENSG00000183346
Chromosome: 10
Canonical length: 208 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome,Basal body,Cytosol

OverviewNCBI Gene

Predicted to enable calcium ion binding activity. Predicted to act upstream of or within sperm flagellum assembly. Predicted to be located in centrosome; cytoplasm; and sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

208 residues, UniProt reviewed canonical sequence.

>Q8IVU9|CABCOCO1
     1  MDFSIIQYSK FMTLLAMSLQ NLKTLHMSLE ESIKWLGEVM AEIGPTHSQK SEDWNIFDVK
    61  QANAIIDYLK ISLFQHYKLY EFMFYSAREE IVIGTEQVIE VVKSACGPFP NPLEEGISFD
   121  IYSTFIEPPT ILDTEMKRLD QEQGPEESQP ETDTSDMDPL VGFTIEDVKS VLDQVTDDIL
   181  IGIQTEINEK LQIQEEAFNA RIEKLKKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CABCOCO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 25 nTPM
testis: 14 nTPM
spinal cord: 14 nTPM
midbrain: 6.8 nTPM
hippocampal formation: 6.2 nTPM
hypothalamus: 5.8 nTPM

Single-cell type

respiratory ciliated cells: 486 nCPM
ependymal cells: 399 nCPM
fallopian tube ciliated cells: 322 nCPM
epididymal efferent duct ciliated cells: 299 nCPM
late primary spermatocytes: 159 nCPM
endometrial ciliated cells: 119 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 17 nTPM
spinal cord: 15 nTPM
white matter: 13 nTPM
medulla oblongata: 13 nTPM
choroid plexus: 9.8 nTPM
pons: 7.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

calcium ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CABCOCO1 as an antibody target. Whether an autoantibody or antibody against CABCOCO1 could matter depends on whether native CABCOCO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CABCOCO1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CABCOCO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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