Seroatlas · Human Serome Atlas

CAAP1

Caspase activity and apoptosis inhibitor 1

Also known as: C9orf82, CAAP, CAAP1_HUMAN, FLJ13657

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H8G2
Gene: CAAP1
Ensembl: ENSG00000120159
Chromosome: 9
Canonical length: 361 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Involved in negative regulation of apoptotic process. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

361 residues, UniProt reviewed canonical sequence.

>Q9H8G2|CAAP1
     1  MTGKKSSREK RRKRSSQEAA AALAAPDIVP ALASGSSGST SGCGSAGGCG SVSCCGNANF
    61  SGSVTGGGSG GSCWGGSSVE RSERRKRRST DSSSVSGSLQ QETKYILPTL EKELFLAEHS
   121  DLEEGGLDLT VSLKPVSFYI SDKKEMLQQC FCIIGEKKLQ KMLPDVLKNC SIEEIKKLCQ
   181  EQLELLSEKK ILKILEGDNG MDSDMEEEAD DGSKMGSDLV SQQDICIDSA SSVRENKQPE
   241  GLELKQGKGE DSDVLSINAD AYDSDIEGPC NEEAAAPEAP ENTVQSEAGQ IDDLEKDIEK
   301  SVNEILGLAE SSPNEPKAAT LAVPPPEDVQ PSAQQLELLE LEMRARAIKA LMKAGDIKKP
   361  A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 26 nTPM
liver: 22 nTPM
adrenal gland: 19 nTPM
rectum: 18 nTPM
parathyroid gland: 18 nTPM
colon: 17 nTPM

Single-cell type

choroid plexus epithelial cells: 229 nCPM
adrenal cortex cells: 139 nCPM
distal convoluted tubule cells: 125 nCPM
myonuclei: 124 nCPM
renal connecting tubule cells: 122 nCPM
lacrimal acinar cells: 109 nCPM

Immune cell

MAIT T-cell: 21 nTPM
NK-cell: 20 nTPM
memory B-cell: 19 nTPM
memory CD8 T-cell: 19 nTPM
naive B-cell: 19 nTPM
T-reg: 19 nTPM

Brain region

choroid plexus: 19 nTPM
hypothalamus: 6.8 nTPM
cerebellum: 6.1 nTPM
thalamus: 5.9 nTPM
cerebral cortex: 5.8 nTPM
white matter: 5.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0.78
gnomAD missense Z: -0.47
DepMap mean gene effect: 0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

Caspase activity and apoptosis inhibitor 1
Caspase activity and apoptosis inhibitor 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAAP1 as an antibody target. Whether an autoantibody or antibody against CAAP1 could matter depends on whether native CAAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CAAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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