Seroatlas · Human Serome Atlas

CA5BP1

Putative inactive carbonic anhydrase 5B-like protein

Also known as: CA5BL_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WTZ4
Gene: CA5BP1
Canonical length: 195 aa

OverviewNCBI Gene

No narrative summary is available for CA5BP1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

195 residues, UniProt reviewed canonical sequence.

>Q8WTZ4|CA5BP1
     1  MTQPPASTSG IMGTLSSWNL KILQINQLHL VHWNAVKFEN FEDAALEENG LAVIGVFLKI
    61  SETSGSPVST GRPKPLARKL RPAQKHWVLQ SRPFLSSQVQ ENCKVTYFHR KHWVRIRPLR
   121  TTPPSWDYTR ICIQREMVPA RIRVLREMVP EAWRCFPNRL PLLSNIRPDF SKAPLAYVKR
   181  WLWTARHPHS LSAAW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CA5BP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

carbonate dehydratase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CA5BP1 as an antibody target. Whether an autoantibody or antibody against CA5BP1 could matter depends on whether native CA5BP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CA5BP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CA5BP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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