C9orf85
Uncharacterized protein C9orf85
Also known as: CI085_HUMAN, MGC61599
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96MD7
- Gene
- C9orf85
- Ensembl
- ENSG00000155621
- Chromosome
- 9
- Canonical length
- 179 aa
- Protein class
- Predicted intracellular proteins, Transporters
- Subcellular location
- Nucleoplasm,Nucleoli,Golgi apparatus
OverviewNCBI Gene
No narrative summary is available for C9orf85 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
179 residues, UniProt reviewed canonical sequence.
>Q96MD7|C9orf85
1 MSSQKGNVAR SRPQKHQNTF SFKNDKFDKS VQTKKINAKL HDGVCQRCKE VLEWRVKYSK
61 YKPLSKPKKC VKCLQKTVKD SYHIMCRPCA CELEVCAKCG KKEDIVIPWS LPLLPRLECS
121 GRILAHHNLR LPCSSDSPAS ASRVAGTTGA HHHAQLIFVF LVEMGFHYVG QAGLELLTSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C9orf85 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.46
- Highest tissue expression
- 11 nTPM
Expression across tissuesHPA
Tissue
- duodenum: 11 nTPM
- spinal cord: 11 nTPM
- skin: 10 nTPM
- ovary: 10 nTPM
- esophagus: 10 nTPM
- blood vessel: 9.8 nTPM
Single-cell type
- esophageal apical cells: 152 nCPM
- oligodendrocytes: 148 nCPM
- sertoli cells: 112 nCPM
- myonuclei: 107 nCPM
- urothelial cells: 97 nCPM
- prostatic glandular cells: 93 nCPM
Immune cell
- basophil: 14 nTPM
- NK-cell: 13 nTPM
- naive CD8 T-cell: 11 nTPM
- eosinophil: 11 nTPM
- MAIT T-cell: 10 nTPM
- plasmacytoid DC: 10 nTPM
Brain region
- white matter: 29 nTPM
- basal ganglia: 22 nTPM
- medulla oblongata: 22 nTPM
- cerebral cortex: 21 nTPM
- thalamus: 21 nTPM
- pons: 21 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.68
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.04
- DepMap mean gene effect
- -0.12
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Protein of unknown function DUF2039
- Uncharacterized conserved protein (DUF2039)
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C9orf85 as an antibody target. Whether an autoantibody or antibody against C9orf85 could matter depends on whether native C9orf85 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C9orf85 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C9orf85 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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