Seroatlas · Human Serome Atlas

C9orf57

Uncharacterized protein C9orf57

Also known as: CI057_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5W0N0
Gene
C9orf57
Ensembl
ENSG00000204669
Chromosome
9
Canonical length
161 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

161 residues, UniProt reviewed canonical sequence.

>Q5W0N0|C9orf57
     1  MKKIEISGTC LSFHLLFGLE IRMRRIVFAG VILFRLLGVI LFRLLGVILF GRLGDLGTCQ
    61  TKPGQYWKEE VHIQDVGGLI CRACNLSLPF HGCLLDLGTC QAEPGQYCKE EVHIQGGIQW
   121  YSVKGCTKNT SECFKSTLVK RILQLHELVT THCCNHSLCN F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C9orf57 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • testis: 11 nTPM
  • heart muscle: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • late primary spermatocytes: 39 nCPM
  • tuft cells: 12 nCPM
  • early primary spermatocytes: 7.6 nCPM
  • breast myoepithelial cells: 6.9 nCPM
  • undifferentiated spermatogonia: 4.2 nCPM
  • megakaryocyte progenitors: 2.7 nCPM

Immune cell

  • basophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 1.4 nTPM
  • cerebral cortex: 1.2 nTPM
  • basal ganglia: 1 nTPM
  • medulla oblongata: 0.8 nTPM
  • thalamus: 0.8 nTPM
  • amygdala: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.75
gnomAD pLI
0
gnomAD missense Z
0.39
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4723
  • Domain of unknown function (DUF4723)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C9orf57 as an antibody target. Whether an autoantibody or antibody against C9orf57 could matter depends on whether native C9orf57 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C9orf57 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C9orf57 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C9orf57. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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