Seroatlas · Human Serome Atlas

C9orf43

Uncharacterized protein C9orf43

Also known as: CI043_HUMAN, MGC17358

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TAL5
Gene: C9orf43
Ensembl: ENSG00000157653
Chromosome: 9
Canonical length: 461 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

No narrative summary is available for C9orf43 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

461 residues, UniProt reviewed canonical sequence.

>Q8TAL5|C9orf43
     1  MDLPDESQWD ETTCGLAVCQ HPQCWATIRR IERGHPRILG SSCKTPLDAE DKLPVLTVVD
    61  ILDSGFAAHH LPECTFTKAH SLLSQSSKFY SKFHGRPPKG LPDKSLINCT NRLPKFPVLN
   121  LNETQLPCPE DVRNMVVLWI PEETEIHVSQ HGKKKRKNSA VKSKSFLGLS GNQSAGTRVG
   181  TPGMIVPPPT PVQLSEQFSS DFLPLWAQSE ALPQDLLKEL LPGGKQTMLC PEMKIKLAMM
   241  KKNLPLEKNR PDSVISSKMF LSIHRLTLER PALRYPERLK KLHNLKTEGY RKQQQRQQQQ
   301  QQQQKKVKTP IKKQEAKKKA KSDPGIQSTS HKHPVTTVHD RLYGYRTLPG QNSDMKQQQQ
   361  MEKGTTSKQD STERPKMNYY DHADFHHSVK SPELYETEPT NKDISAPVDA VPEAQAARQK
   421  KISFNFSEIM ASTGWNSELK LLRILQDTDD EDEEDQSSGA E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C9orf43 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

testis: 44 nTPM
bone marrow: 1.8 nTPM
adrenal gland: 1.5 nTPM
liver: 1.5 nTPM
pituitary gland: 1.4 nTPM
kidney: 1.3 nTPM

Single-cell type

late spermatids: 364 nCPM
late primary spermatocytes: 169 nCPM
early spermatids: 101 nCPM
early primary spermatocytes: 62 nCPM
epicardial cells: 43 nCPM
cardiomyocytes: 22 nCPM

Immune cell

memory CD8 T-cell: 0.4 nTPM
naive CD8 T-cell: 0.4 nTPM
neutrophil: 0.4 nTPM
gdT-cell: 0.3 nTPM
intermediate monocyte: 0.3 nTPM
memory B-cell: 0.3 nTPM

Brain region

midbrain: 3 nTPM
medulla oblongata: 2.4 nTPM
spinal cord: 2.3 nTPM
white matter: 2.3 nTPM
hypothalamus: 2.2 nTPM
pons: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0
gnomAD missense Z: 0.17
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4647
Domain of unknown function (DUF4647)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C9orf43 as an antibody target. Whether an autoantibody or antibody against C9orf43 could matter depends on whether native C9orf43 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C9orf43 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C9orf43 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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