C9orf163
Uncharacterized protein C9orf163
Also known as: CI163_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for C9orf163 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
203 residues, UniProt reviewed canonical sequence.
>Q8N9P6|C9orf163
1 MPGPLTCTPA WQGQGRAAAF LCCSFQRAGA VVGVPARWHR GRLSSQQRLR SSLGGSHPCP
61 QLGRRLVREG VISVPRQQGR RRCRESFSPA DVAPGPICSA NICLSGVRFL TCLNRVREHV
121 VGPSPSPAAP ICFFPVVEAL CTLRGRRCHC LPFPKRGMQR WMLPLRRGAR LLPLASSKNP
181 RARSPGLDPL GSSETLWSHR GGHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C9orf163 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.74
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD missense Z
- 0.31
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C9orf163 as an antibody target. Whether an autoantibody or antibody against C9orf163 could matter depends on whether native C9orf163 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C9orf163 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C9orf163 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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