C9orf153
Uncharacterized protein C9orf153
Also known as: bA507D14.1, CI153_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5TBE3
- Gene
- C9orf153
- Ensembl
- ENSG00000187753
- Chromosome
- 9
- Canonical length
- 101 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nuclear bodies,Vesicles,Plasma membrane
OverviewNCBI Gene
No narrative summary is available for C9orf153 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
101 residues, UniProt reviewed canonical sequence.
>Q5TBE3|C9orf153
1 MFLTGDTSPA EDNREATLPQ CSLPELYACI ENFNKESKKS NLLKMHGISL NEAQEVLARN
61 LNVMSFTRGA DVRGDLQPVI SVNKMNKPGK HRKTPSPKIN KLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C9orf153 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.63
- Highest tissue expression
- 19 nTPM
Expression across tissuesHPA
Tissue
- testis: 19 nTPM
- bone marrow: 2.2 nTPM
- placenta: 0.8 nTPM
- retina: 0.6 nTPM
- adrenal gland: 0.4 nTPM
- gallbladder: 0.4 nTPM
Single-cell type
- early spermatids: 680 nCPM
- late spermatids: 503 nCPM
- late primary spermatocytes: 261 nCPM
- myonuclei: 38 nCPM
- choroid plexus epithelial cells: 22 nCPM
- cardiomyocytes: 20 nCPM
Immune cell
- classical monocyte: 1.6 nTPM
- total PBMC: 1.5 nTPM
- myeloid DC: 1.2 nTPM
- basophil: 0.7 nTPM
- intermediate monocyte: 0.5 nTPM
- neutrophil: 0.4 nTPM
Brain region
- cerebellum: 7.9 nTPM
- white matter: 7.1 nTPM
- cerebral cortex: 6.8 nTPM
- midbrain: 6.4 nTPM
- pons: 6.1 nTPM
- medulla oblongata: 5.9 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.83
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 0.2
- DepMap mean gene effect
- 0.08
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Uncharacterized protein C9orf153-like
- Family of unknown function (DUF5532)
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C9orf153 as an antibody target. Whether an autoantibody or antibody against C9orf153 could matter depends on whether native C9orf153 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C9orf153 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C9orf153 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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