Seroatlas · Human Serome Atlas

C9orf152

Uncharacterized protein C9orf152

Also known as: bA470J20.2, CI152_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5JTZ5
Gene
C9orf152
Ensembl
ENSG00000188959
Chromosome
9
Canonical length
239 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

No narrative summary is available for C9orf152 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

239 residues, UniProt reviewed canonical sequence.

>Q5JTZ5|C9orf152
     1  MEGLPCPCPA LPHFWQLRSH LMAEGSRTQA PGKGPPLSIQ FLRAQYEGLK RQQRTQAHLL
    61  VLPKGGNTPA PAESMVNAVW INKERRSSLS LEEADSEVEG RLEEAAQGCL QAPKSPWHTH
   121  LEMHCLVQTS PQDTSHQVHH RGKLVGSDQR LPPEGDTHLF ETNQMTQQGT GIPEAAQLPC
   181  QVGNTQTKAV ESGLKFSTQC PLSIKNPHRS GKPAYYPFPQ RKTPRISQAA RNLGLYGSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C9orf152 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • rectum: 39 nTPM
  • stomach: 32 nTPM
  • colon: 31 nTPM
  • salivary gland: 24 nTPM
  • duodenum: 18 nTPM
  • prostate: 16 nTPM

Single-cell type

  • parietal cells: 140 nCPM
  • goblet cells: 129 nCPM
  • gastric chief cells: 104 nCPM
  • enteric stem cells: 88 nCPM
  • mucous neck cells: 83 nCPM
  • enteric transient amplifying cells: 75 nCPM

Immune cell

  • basophil: 0.1 nTPM
  • neutrophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • white matter: 1.8 nTPM
  • medulla oblongata: 1.7 nTPM
  • pons: 1.7 nTPM
  • amygdala: 1.6 nTPM
  • thalamus: 1.6 nTPM
  • cerebral cortex: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.05
gnomAD pLI
0.02
gnomAD missense Z
-0.65
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C9orf152 as an antibody target. Whether an autoantibody or antibody against C9orf152 could matter depends on whether native C9orf152 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C9orf152 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C9orf152 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C9orf152. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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