Seroatlas · Human Serome Atlas

C8orf90

Uncharacterized protein C8orf90

Also known as: CHO90_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A2R8Y2Y2
Gene
C8orf90
Canonical length
192 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for C8orf90 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

192 residues, UniProt reviewed canonical sequence.

>A0A2R8Y2Y2|C8orf90
     1  MASSCPGTPS PAGLPPPSVA TPGETLGPAA PPEPAFPDIY GGDAQLWEAH FRGIGRAYRA
    61  LGKQDDFAIR VLTENFTLPF PFAWPPGSDP ACGPLFYDPR DRADFDFLLR GPGASPPALL
   121  RPLHATAQAA MRKRRLERLA LSCARARGPG PASSCCCPAP PPPSRSPRPA LPATAPPGWP
   181  RPRRCPESEQ NK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C8orf90 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • testis: 13 nTPM
  • cerebral cortex: 2.4 nTPM
  • amygdala: 1.4 nTPM
  • hypothalamus: 1.4 nTPM
  • hippocampal formation: 1 nTPM
  • skin: 0.6 nTPM

Single-cell type

  • late primary spermatocytes: 224 nCPM
  • early spermatids: 185 nCPM
  • late spermatids: 72 nCPM
  • brain excitatory neurons: 2.8 nCPM
  • other brain neurons: 2.4 nCPM
  • brain inhibitory neurons: 1.3 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 9.8 nTPM
  • cerebral cortex: 4.2 nTPM
  • medulla oblongata: 3.1 nTPM
  • basal ganglia: 2.1 nTPM
  • hippocampal formation: 1.9 nTPM
  • white matter: 1.8 nTPM

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C8orf90 as an antibody target. Whether an autoantibody or antibody against C8orf90 could matter depends on whether native C8orf90 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C8orf90 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C8orf90 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C8orf90. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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