Seroatlas · Human Serome Atlas

C8orf89

Putative uncharacterized protein C8orf89

Also known as: CH089_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DMQ9
Gene
C8orf89
Ensembl
ENSG00000274443
Chromosome
8
Canonical length
161 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for C8orf89 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

161 residues, UniProt reviewed canonical sequence.

>P0DMQ9|C8orf89
     1  MSVLSPEIKC ETSKFTRSSF GSCLIFESSW KKAVLETQKI KKEYTTAFGL EELKECIKMP
    61  YLPGLQSCQK SVSSTPLEVP KRLPRADAEV SAVRLKKTKE TCSVAPLWEK SKGSGFSDPL
   121  TGAPSQYLER LSKIAILEYD TIRQETTTKS KKSKKRDLRD R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C8orf89 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
7.1 nTPM

Expression across tissuesHPA

Tissue

  • testis: 7.1 nTPM
  • lymph node: 1 nTPM
  • cervix: 0.9 nTPM
  • tonsil: 0.8 nTPM
  • epididymis: 0.7 nTPM
  • ovary: 0.6 nTPM

Single-cell type

  • late primary spermatocytes: 62 nCPM
  • decidual stromal cells: 9 nCPM
  • early spermatids: 6.5 nCPM
  • hepatic stellate cells: 6.5 nCPM
  • early primary spermatocytes: 5.9 nCPM
  • retinal ganglion cells: 3.9 nCPM

Immune cell

  • naive B-cell: 4.8 nTPM
  • memory B-cell: 2.7 nTPM
  • NK-cell: 0.7 nTPM
  • myeloid DC: 0.6 nTPM
  • intermediate monocyte: 0.2 nTPM
  • naive CD4 T-cell: 0.2 nTPM

Brain region

  • hypothalamus: 0.7 nTPM
  • amygdala: 0.5 nTPM
  • cerebral cortex: 0.4 nTPM
  • spinal cord: 0.4 nTPM
  • white matter: 0.4 nTPM
  • basal ganglia: 0.3 nTPM

Protein domainsUniProt · Pfam · InterPro

  • Family of unknown function DUF5537
  • Family of unknown function (DUF5537)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C8orf89 as an antibody target. Whether an autoantibody or antibody against C8orf89 could matter depends on whether native C8orf89 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C8orf89 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C8orf89 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C8orf89. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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