Seroatlas · Human Serome Atlas

C8orf88

Uncharacterized protein C8orf88

Also known as: CH088_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DMB2
Gene
C8orf88
Ensembl
ENSG00000253250
Chromosome
8
Canonical length
117 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to enable eukaryotic initiation factor 4E binding activity. Predicted to be involved in negative regulation of translational initiation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>P0DMB2|C8orf88
     1  METKKLIGKP LQPARPVRHL TSPPGAVFPF NFQNEYPCNT QCIQSGVSRC KTNGMQAFSQ
    61  GLNEQQQQQS PVKKERIKYS RDFLLKLSSV SICRKKPDFL PDHPIVLQKP ENNQSFK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C8orf88 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
86 nTPM

Expression across tissuesHPA

Tissue

  • testis: 86 nTPM
  • heart muscle: 34 nTPM
  • smooth muscle: 29 nTPM
  • colon: 28 nTPM
  • blood vessel: 24 nTPM
  • seminal vesicle: 22 nTPM

Single-cell type

  • late primary spermatocytes: 704 nCPM
  • early spermatids: 687 nCPM
  • early primary spermatocytes: 169 nCPM
  • late spermatids: 158 nCPM
  • epicardial cells: 50 nCPM
  • sertoli cells: 49 nCPM

Immune cell

  • NK-cell: 3.8 nTPM
  • plasmacytoid DC: 3.2 nTPM
  • naive CD8 T-cell: 1.4 nTPM
  • MAIT T-cell: 1.3 nTPM
  • memory B-cell: 1.1 nTPM
  • memory CD8 T-cell: 1 nTPM

Brain region

  • choroid plexus: 11 nTPM
  • white matter: 9.3 nTPM
  • hypothalamus: 7.4 nTPM
  • spinal cord: 7.4 nTPM
  • medulla oblongata: 6.9 nTPM
  • basal ganglia: 6.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.88
gnomAD pLI
0.44
gnomAD missense Z
0.63
DepMap mean gene effect
-0.01
DepMap dependency class
selective

OntologyGO

Biological processes

Molecular functions

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C8orf88 as an antibody target. Whether an autoantibody or antibody against C8orf88 could matter depends on whether native C8orf88 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C8orf88 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C8orf88 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C8orf88. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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