Seroatlas · Human Serome Atlas

C8orf82

UPF0598 protein C8orf82

Also known as: CH082_HUMAN, MGC70857

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P1X6
Gene: C8orf82
Ensembl: ENSG00000213563
Chromosome: 8
Canonical length: 216 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

216 residues, UniProt reviewed canonical sequence.

>Q6P1X6|C8orf82
     1  MWPPCGTLRT LALARSRGAR ACSGDGGVSY TQGQSPEPRT REYFYYVDHQ GQLFLDDSKM
    61  KNFITCFKDP QFLVTFFSRL RPNRSGRYEA AFPFLSPCGR ERNFLRCEDR PVVFTHLLTA
   121  DHGPPRLSYC GGGEALAVPF EPARLLPLAA NGRLYHPAPE RAGGVGLVRS ALAFELSACF
   181  EYGPGAPALP SHVRWQGRRL ALTMDLAPLL LAARSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C8orf82 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

liver: 36 nTPM
prostate: 26 nTPM
kidney: 17 nTPM
heart muscle: 17 nTPM
esophagus: 16 nTPM
ovary: 15 nTPM

Single-cell type

parietal cells: 11 nCPM
prostatic club cells: 5.5 nCPM
oocytes: 4.6 nCPM
endometrial secretory cells: 4.2 nCPM
retinal horizontal cells: 4 nCPM
endometrial luminal cells: 3.6 nCPM

Immune cell

classical monocyte: 0.3 nTPM
eosinophil: 0.3 nTPM
non-classical monocyte: 0.3 nTPM
memory B-cell: 0.2 nTPM
naive B-cell: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM

Brain region

white matter: 27 nTPM
cerebellum: 26 nTPM
cerebral cortex: 24 nTPM
medulla oblongata: 23 nTPM
amygdala: 22 nTPM
pons: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.9
gnomAD pLI: 0
gnomAD missense Z: 0.14
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4505
Domain of unknown function (DUF4505)

InteractionsUniProt · HPA

Protein binding partners of C8orf82 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ETFA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C8orf82 as an antibody target. Whether an autoantibody or antibody against C8orf82 could matter depends on whether native C8orf82 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C8orf82 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C8orf82 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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