C8orf76
Uncharacterized protein C8orf76
Also known as: CH076_HUMAN, FLJ14825
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96K31
- Gene
- C8orf76
- Ensembl
- ENSG00000189376
- Chromosome
- 8
- Canonical length
- 380 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
No narrative summary is available for C8orf76 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
380 residues, UniProt reviewed canonical sequence.
>Q96K31|C8orf76
1 MDSGCWLFGG EFEDSVFEER PERRSGPPAS YCAKLCEPQW FYEETESSDD VEVLTLKKFK
61 GDLAYRRQEY QKALQEYSSI SEKLSSTNFA MKRDVQEGQA RCLAHLGRHM EALEIAANLE
121 NKATNTDHLT TVLYLQLAIC SSLQNLEKTI FCLQKLISLH PFNPWNWGKL AEAYLNLGPA
181 LSAALASSQK QHSFTSSDKT IKSFFPHSGK DCLLCFPETL PESSLFSVEA NSSNSQKNEK
241 ALTNIQNCMA EKRETVLIET QLKACASFIR TRLLLQFTQP QQTSFALERN LRTQQEIEDK
301 MKGFSFKEDT LLLIAEVMGE DIPEKIKDEV HPEVKCVGSV ALTALVTVSS EEFEDKWFRK
361 IKDHFCPFEN QFHTEIQILALocalizationUniProt · AlphaFold · HPA
Whether an antibody against C8orf76 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.41
- Highest tissue expression
- 18 nTPM
Expression across tissuesHPA
Tissue
- liver: 18 nTPM
- pituitary gland: 18 nTPM
- esophagus: 16 nTPM
- skeletal muscle: 16 nTPM
- adrenal gland: 14 nTPM
- spleen: 14 nTPM
Single-cell type
- esophageal apical cells: 86 nCPM
- retinal horizontal cells: 80 nCPM
- syncytiotrophoblasts: 47 nCPM
- oocytes: 46 nCPM
- extravillous trophoblasts: 39 nCPM
- pancreatic islet cells: 38 nCPM
Immune cell
- eosinophil: 28 nTPM
- intermediate monocyte: 21 nTPM
- T-reg: 21 nTPM
- basophil: 20 nTPM
- myeloid DC: 19 nTPM
- classical monocyte: 18 nTPM
Brain region
- choroid plexus: 9.5 nTPM
- white matter: 9.4 nTPM
- cerebellum: 9.3 nTPM
- basal ganglia: 8.2 nTPM
- spinal cord: 8.2 nTPM
- thalamus: 8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.61
- gnomAD pLI
- 0
- gnomAD missense Z
- 0
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 18% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C8orf76 as an antibody target. Whether an autoantibody or antibody against C8orf76 could matter depends on whether native C8orf76 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C8orf76 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C8orf76 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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