C8orf58
Uncharacterized protein C8orf58
Also known as: CH058_HUMAN, FLJ34715
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8NAV2
- Gene
- C8orf58
- Ensembl
- ENSG00000241852
- Chromosome
- 8
- Canonical length
- 365 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nuclear bodies
OverviewNCBI Gene
No narrative summary is available for C8orf58 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
365 residues, UniProt reviewed canonical sequence.
>Q8NAV2|C8orf58
1 MMGRRRAFAV DGRDGAGEGL ARGCIVPGVT STYRRIPDAA HGCSSWERGD KFRGVGREAL
61 FLKLASRDSG VEMAVGDSPL AALPGLSQDS LDFESSGSSE PPAQVGRLLA SQKLGEVLER
121 SRRLPTAPTS LSGQHRSLRL ASKPEREVPL GAGQQESMEA DTDLEAGLEE EAVGGLGPGA
181 WACLPGQGLR YLEHLCLVLE QMARLQQLYL QLRIQRPPGD PGEEESTRAP LPSPLHTPGN
241 RGQGPWELLS QTEHTGAKAA SPPKVEVPSA NPPRLPETPV EPTYHLPSSQ GHKRDISHWD
301 KVKVLLNRIC RRSHHHPEPP APPDGSDPRI ESRDLPERPQ CRPHRKTFMP SLVVKKQRAK
361 NLSVGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C8orf58 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.7
- Highest tissue expression
- 25 nTPM
Expression across tissuesHPA
Tissue
- spleen: 25 nTPM
- testis: 16 nTPM
- placenta: 16 nTPM
- cerebellum: 15 nTPM
- skin: 13 nTPM
- kidney: 13 nTPM
Single-cell type
- syncytiotrophoblasts: 62 nCPM
- migrating cytotrophoblasts: 44 nCPM
- extravillous trophoblasts: 41 nCPM
- cytotrophoblasts: 28 nCPM
- podocytes: 26 nCPM
- decidual stromal cells: 19 nCPM
Immune cell
- eosinophil: 1.2 nTPM
- naive CD4 T-cell: 0.6 nTPM
- naive CD8 T-cell: 0.5 nTPM
- intermediate monocyte: 0.4 nTPM
- memory B-cell: 0.4 nTPM
- naive B-cell: 0.4 nTPM
Brain region
- cerebellum: 18 nTPM
- medulla oblongata: 9.6 nTPM
- hypothalamus: 8.4 nTPM
- thalamus: 8.4 nTPM
- pons: 8.3 nTPM
- amygdala: 8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.06
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.32
- DepMap mean gene effect
- 0.13
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Domain of unknown function DUF4657
- Domain of unknown function (DUF4657)
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C8orf58 as an antibody target. Whether an autoantibody or antibody against C8orf58 could matter depends on whether native C8orf58 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C8orf58 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C8orf58 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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