Seroatlas · Human Serome Atlas

C8orf44

Putative uncharacterized protein C8orf44

Also known as: CH044_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96CB5
Gene: C8orf44
Canonical length: 159 aa

OverviewNCBI Gene

No narrative summary is available for C8orf44 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

159 residues, UniProt reviewed canonical sequence.

>Q96CB5|C8orf44
     1  MRKNESYLNQ PAPPIPIPTL SLMGGCREHF ENHWKGRARW LMPVIPALWE AKAGRSPEVR
    61  SSKPAWPTWR NPIFTKNTKI SQVLELFLNY QSLICALEKQ KRQKGSLAIF CWSFQGGCVS
   121  KRPDVPSLKS QKPKRKRITG RKRLSKGFWS LLFSNLGRF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C8orf44 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about C8orf44.

Disease | ImmuneIEDB

Conditions an epitope on C8orf44 was assayed in.

lung adenocarcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.51
gnomAD pLI: 0.21
gnomAD missense Z: -0.29

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C8orf44 as an antibody target. Whether an autoantibody or antibody against C8orf44 could matter depends on whether native C8orf44 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C8orf44 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C8orf44 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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