Seroatlas · Human Serome Atlas

C8orf34

Uncharacterized protein C8orf34

Also known as: CH034_HUMAN, vest-1, VEST1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q49A92
Gene
C8orf34
Ensembl
ENSG00000165084
Chromosome
8
Canonical length
538 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Golgi apparatus

OverviewNCBI Gene

This gene encodes a protein that is related to the cyclic AMP dependent protein kinase regulators. Naturally occurring mutations in this gene are associated with an increased risk for severe toxicities, such as diarrhea and neutropenia, in patients undergoing chemotherapeutic treatment. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

538 residues, UniProt reviewed canonical sequence.

>Q49A92|C8orf34
     1  MSSPLASELS ELAALRPGFR LSAPHARVAP RAATHARGRG RASHAGQPRL RSSCPGPSPG
    61  KRRVVPSGGA QPRVLPALSS RSHLFPMASH PQTRIQAYLE KNKIGPLFEE LMTKLITETP
   121  DQPIPFLIDH LQSKQGNRGQ LQRTLSGSAA LWAESEKSES KGTRRDFRSY DKPWQLNAKK
   181  PKKSKSDLAV SNISPPSPDS KSLPRSVEHP KWNWRTKPQS RDFDELNHIL QESKKLGKAL
   241  ENLSRSIAIS DELDKETVTF NSSLLRPRVI GEWIGREEND ADPLAAEMLQ PPIPRSKNDQ
   301  WESEDSGSSP AGSLKMEPKN KGLKQQQQQH KKLLAAMLSQ DSFESIHSPT PSVTEEDIDN
   361  EDDAMELLED LNDLRMEGVT TLVPSGSKFN QGRPTYPAEP QAKVTLNICS RCARLQGDNL
   421  EERTEESLPI LHSPDEKIPD SFDSLPGTEE ALMEEGDEFE KASKLTGPGE ASSGVGHSLK
   481  NYMEEDESLK QLQVVHQPWI LPSDTESEGV EAEQEKRSAD LLLCVPCSSC PTLVYSGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C8orf34 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
8.6 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 8.6 nTPM
  • parathyroid gland: 6.9 nTPM
  • blood vessel: 5.9 nTPM
  • hippocampal formation: 3.7 nTPM
  • cerebral cortex: 3.4 nTPM
  • hypothalamus: 3.3 nTPM

Single-cell type

  • ependymal cells: 2,521 nCPM
  • respiratory ciliated cells: 962 nCPM
  • endometrial ciliated cells: 450 nCPM
  • fallopian tube ciliated cells: 447 nCPM
  • transitional alveolar cells: 374 nCPM
  • alveolar cells type 2: 306 nCPM

Immune cell

  • neutrophil: 0.5 nTPM
  • basophil: 0.4 nTPM
  • naive CD8 T-cell: 0.3 nTPM
  • plasmacytoid DC: 0.3 nTPM
  • gdT-cell: 0.2 nTPM
  • MAIT T-cell: 0.2 nTPM

Brain region

  • midbrain: 38 nTPM
  • medulla oblongata: 30 nTPM
  • hypothalamus: 29 nTPM
  • hippocampal formation: 29 nTPM
  • white matter: 28 nTPM
  • basal ganglia: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.1
gnomAD pLI
0
gnomAD missense Z
0.66
DepMap mean gene effect
-0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF5586
  • Family of unknown function (DUF5586)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C8orf34 as an antibody target. Whether an autoantibody or antibody against C8orf34 could matter depends on whether native C8orf34 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C8orf34 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C8orf34 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C8orf34. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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