Seroatlas · Human Serome Atlas

C8G

Complement component C8 gamma chain

Also known as: CO8G_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P07360
Gene
C8G
Ensembl
ENSG00000176919
Chromosome
9
Canonical length
202 aa
Protein class
Human disease related genes, Plasma proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011]

Canonical amino-acid sequenceUniProt

202 residues, UniProt reviewed canonical sequence.

>P07360|C8G
     1  MLPPGTATLL TLLLAAGSLG QKPQRPRRPA SPISTIQPKA NFDAQQFAGT WLLVAVGSAC
    61  RFLQEQGHRA EATTLHVAPQ GTAMAVSTFR KLDGICWQVR QLYGDTGVLG RFLLQARDAR
   121  GAVHVVVAET DYQSFAVLYL ERAGQLSVKL YARSLPVSDS VLSGFEQRVQ EAHLTEDQIF
   181  YFPKYGFCEA ADQFHVLDEV RR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C8G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
522 nTPM

Expression across tissuesHPA

Tissue

  • liver: 522 nTPM
  • duodenum: 29 nTPM
  • small intestine: 17 nTPM
  • gallbladder: 2.3 nTPM
  • skeletal muscle: 2.1 nTPM
  • kidney: 2 nTPM

Single-cell type

  • hepatocytes: 1,126 nCPM
  • enterocytes: 118 nCPM
  • colonocytes: 31 nCPM
  • cholangiocytes: 23 nCPM
  • neuroendocrine cells: 20 nCPM
  • epididymal principal cells: 18 nCPM

Immune cell

  • gdT-cell: 0.6 nTPM
  • naive CD8 T-cell: 0.4 nTPM
  • memory CD8 T-cell: 0.3 nTPM
  • plasmacytoid DC: 0.2 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • pons: 0.6 nTPM
  • amygdala: 0.4 nTPM
  • basal ganglia: 0.4 nTPM
  • cerebellum: 0.4 nTPM
  • cerebral cortex: 0.4 nTPM
  • hippocampal formation: 0.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about C8G.

Disease | ImmuneIEDB

Conditions an epitope on C8G was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.93
gnomAD pLI
0
gnomAD missense Z
-0.36
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C8G as an antibody target. Whether an autoantibody or antibody against C8G could matter depends on whether native C8G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C8G is annotated at the cell surface, where native C8G is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label C8G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C8G. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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