C7orf57
Uncharacterized protein C7orf57
Also known as: CG057_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8NEG2
- Gene
- C7orf57
- Ensembl
- ENSG00000164746
- Chromosome
- 7
- Canonical length
- 295 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Primary cilium,Primary cilium transition zone,Basal body,Cytosol
OverviewNCBI Gene
No narrative summary is available for C7orf57 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
295 residues, UniProt reviewed canonical sequence.
>Q8NEG2|C7orf57
1 MRNTSKELQG ATHRYAPCDW YYHVPVKRSE KAVDAPPASQ IPGLSNLGDS HSENLPGTRR
61 YWIKETDSEY VKLAKQGGRP DLLKHFAPGT RKGSPVAYSL PDWYIHHSKP PTASQQEVRA
121 VSMPDYMVHE EFNPDQANGS YASRRGPFDF DMKTVWQREA EELEKEKKKL RLPAIDSKYL
181 SKAGTPLGPK NPAGSRLSFP PVPGQKNSSP TNFSKLISNG YKDEWLQQQQ RADSDKRTPK
241 TSRASVLSQS PRDLEGPQDA ARLQDAEASE GPEDTPESSQ SPEESVSAST PAELKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C7orf57 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 13 nTPM
Expression across tissuesHPA
Tissue
- fallopian tube: 13 nTPM
- choroid plexus: 7.4 nTPM
- testis: 3.5 nTPM
- lung: 2.1 nTPM
- hypothalamus: 1.8 nTPM
- hippocampal formation: 1.6 nTPM
Single-cell type
- respiratory ciliated cells: 225 nCPM
- fallopian tube ciliated cells: 150 nCPM
- ependymal cells: 138 nCPM
- epididymal efferent duct ciliated cells: 108 nCPM
- endometrial ciliated cells: 80 nCPM
- respiratory deuterosomal cells: 47 nCPM
Immune cell
- MAIT T-cell: 0.3 nTPM
- gdT-cell: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- choroid plexus: 14 nTPM
- medulla oblongata: 8.8 nTPM
- midbrain: 8.1 nTPM
- spinal cord: 6.4 nTPM
- white matter: 4.3 nTPM
- pons: 2.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.58
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.55
- DepMap mean gene effect
- 0.15
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Protein of unknown function DUF5524
- Family of unknown function (DUF5524)
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C7orf57 as an antibody target. Whether an autoantibody or antibody against C7orf57 could matter depends on whether native C7orf57 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C7orf57 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C7orf57 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...