C7orf25
UPF0415 protein C7orf25
Also known as: CG025_HUMAN, MGC2821
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BPX7
- Gene
- C7orf25
- Ensembl
- ENSG00000136197
- Chromosome
- 7
- Canonical length
- 421 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
No narrative summary is available for C7orf25 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
421 residues, UniProt reviewed canonical sequence.
>Q9BPX7|C7orf25
1 MSAHSMLCER IAIAKELIKR AESLSRSRKG GIEGGAKLCS KLKAELKFLQ KVEAGKVAIK
61 ESHLQSTNLT HLRAIVESAE NLEEVVSVLH VFGYTDTLGE KQTLVVDVVA NGGHTWVKAI
121 GRKAEALHNI WLGRGQYGDK SIIEQAEDFL QASHQQPVQY SNPHIIFAFY NSVSSPMAEK
181 LKEMGISVRG DIVAVNALLD HPEELQPSES ESDDEGPELL QVTRVDRENI LASVAFPTEI
241 KVDVCKRVNL DITTLITYVS ALSYGGCHFI FKEKVLTEQA EQERKEQVLP QLEAFMKDKE
301 LFACESAVKD FQSILDTLGG PGERERATVL IKRINVVPDQ PSERALRLVA SSKINSRSLT
361 IFGTGDTLKA ITMTANSGFV RAANNQGVKF SVFIHQPRAL TESKEALATP LPKDYTTDSE
421 HLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C7orf25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 5.1 nTPM
Expression across tissuesHPA
Tissue
- spinal cord: 5.1 nTPM
- midbrain: 5 nTPM
- hypothalamus: 4.5 nTPM
- cerebral cortex: 4.3 nTPM
- amygdala: 4.2 nTPM
- hippocampal formation: 4.1 nTPM
Single-cell type
- oligodendrocytes: 8.8 nCPM
- other brain neurons: 8.1 nCPM
- bergmann glia: 7.7 nCPM
- oligodendrocyte progenitor cells: 7.4 nCPM
- brain excitatory neurons: 6.6 nCPM
- megakaryocytes: 6.2 nCPM
Immune cell
- basophil: 38 nTPM
- eosinophil: 17 nTPM
- neutrophil: 9.1 nTPM
- MAIT T-cell: 2.5 nTPM
- non-classical monocyte: 2.4 nTPM
- memory B-cell: 2.3 nTPM
Brain region
- cerebral cortex: 15 nTPM
- white matter: 15 nTPM
- pons: 13 nTPM
- hypothalamus: 13 nTPM
- midbrain: 12 nTPM
- thalamus: 12 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.59
- gnomAD pLI
- 0.35
- gnomAD missense Z
- 1.23
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Domain of unknown function DUF1308
- Domain of unknown function DUF5614
- Protein of unknown function (DUF1308)
- Family of unknown function (DUF5614)
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C7orf25 as an antibody target. Whether an autoantibody or antibody against C7orf25 could matter depends on whether native C7orf25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C7orf25 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C7orf25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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