C6orf62
Uncharacterized protein C6orf62
Also known as: CF062_HUMAN, DKFZP564G182, FLJ12619, XTP12
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9GZU0
- Gene
- C6orf62
- Ensembl
- ENSG00000112308
- Chromosome
- 6
- Canonical length
- 229 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
No narrative summary is available for C6orf62 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
229 residues, UniProt reviewed canonical sequence.
>Q9GZU0|C6orf62
1 MGDPNSRKKQ ALNRLRAQLR KKKESLADQF DFKMYIAFVF KEKKKKSALF EVSEVIPVMT
61 NNYEENILKG VRDSSYSLES SLELLQKDVV QLHAPRYQSM RRDVIGCTQE MDFILWPRND
121 IEKIVCLLFS RWKESDEPFR PVQAKFEFHH GDYEKQFLHV LSRKDKTGIV VNNPNQSVFL
181 FIDRQHLQTP KNKATIFKLC SICLYLPQEQ LTHWAVGTIE DHLRPYMPELocalizationUniProt · AlphaFold · HPA
Whether an antibody against C6orf62 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.31
- Highest tissue expression
- 147 nTPM
Expression across tissuesHPA
Tissue
- spleen: 147 nTPM
- retina: 140 nTPM
- lymph node: 135 nTPM
- tonsil: 134 nTPM
- thymus: 124 nTPM
- testis: 117 nTPM
Single-cell type
- kupffer cells: 704 nCPM
- neutrophils: 391 nCPM
- neutrophil progenitors: 277 nCPM
- microglia: 249 nCPM
- platelets: 226 nCPM
- parietal cells: 218 nCPM
Immune cell
- total PBMC: 523 nTPM
- non-classical monocyte: 279 nTPM
- eosinophil: 273 nTPM
- intermediate monocyte: 254 nTPM
- classical monocyte: 247 nTPM
- naive CD8 T-cell: 242 nTPM
Brain region
- thalamus: 194 nTPM
- medulla oblongata: 181 nTPM
- midbrain: 180 nTPM
- spinal cord: 152 nTPM
- white matter: 150 nTPM
- basal ganglia: 148 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.24
- gnomAD pLI
- 0.98
- gnomAD missense Z
- 1.35
- DepMap mean gene effect
- 0.09
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- C6orf62 domain
- Domain of unknown function (DUF4566)
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C6orf62 as an antibody target. Whether an autoantibody or antibody against C6orf62 could matter depends on whether native C6orf62 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C6orf62 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C6orf62 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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