C6orf52
Putative uncharacterized protein C6orf52
Also known as: CF052_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5T4I8
- Gene
- C6orf52
- Ensembl
- ENSG00000137434
- Chromosome
- 6
- Canonical length
- 152 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nuclear speckles,Intermediate filaments
OverviewNCBI Gene
No narrative summary is available for C6orf52 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
152 residues, UniProt reviewed canonical sequence.
>Q5T4I8|C6orf52
1 MAQPESSADF GIAQQNNYYC YWQSLPSAIR VKQEFQPSQS YRYGNWYARQ HGSYLLSGYS
61 YGCAVDGNGK DCFSAHETPE HTAGTLVMPK ETTPLAENQD EDPLEDPHLH LNIEESNQEF
121 MVKSEELYDS LMNCHWQPLD TVHSEIPDET PKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C6orf52 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 13 nTPM
Expression across tissuesHPA
Tissue
- testis: 13 nTPM
- amygdala: 4.3 nTPM
- hypothalamus: 4.2 nTPM
- kidney: 4.2 nTPM
- midbrain: 3.9 nTPM
- hippocampal formation: 3.7 nTPM
Single-cell type
- oocytes: 1,243 nCPM
- late primary spermatocytes: 78 nCPM
- early spermatids: 36 nCPM
- endometrial ciliated cells: 33 nCPM
- fallopian tube ciliated cells: 30 nCPM
- late spermatids: 25 nCPM
Immune cell
- T-reg: 4.2 nTPM
- eosinophil: 2.7 nTPM
- memory CD4 T-cell: 0.8 nTPM
- gdT-cell: 0.7 nTPM
- memory CD8 T-cell: 0.6 nTPM
- myeloid DC: 0.6 nTPM
Brain region
- choroid plexus: 3.8 nTPM
- midbrain: 3.3 nTPM
- medulla oblongata: 2.9 nTPM
- hypothalamus: 2.6 nTPM
- white matter: 2.6 nTPM
- pons: 2.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.66
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.68
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C6orf52 as an antibody target. Whether an autoantibody or antibody against C6orf52 could matter depends on whether native C6orf52 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C6orf52 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C6orf52 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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