C6orf50
Putative uncharacterized protein C6orf50
Also known as: CF050_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for C6orf50 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
102 residues, UniProt reviewed canonical sequence.
>Q9HD87|C6orf50
1 MANTQLDHLH YTTEFTRNDL LIICKKFNLM LMDEDIISLL AIFIKMCLWL WKQFLKRGSK
61 CSETSELLEK VKLQLAFTAY KYVDICFPEQ MAYSRYIRWY IHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C6orf50 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.46
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD missense Z
- -0.2
OntologyGO
Cellular components
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C6orf50 as an antibody target. Whether an autoantibody or antibody against C6orf50 could matter depends on whether native C6orf50 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C6orf50 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C6orf50 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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