Seroatlas · Human Serome Atlas

C6orf163

Uncharacterized protein C6orf163

Also known as: CF163_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TEZ5
Gene: C6orf163
Ensembl: ENSG00000203872
Chromosome: 6
Canonical length: 329 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

No narrative summary is available for C6orf163 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

329 residues, UniProt reviewed canonical sequence.

>Q5TEZ5|C6orf163
     1  MIRNSDYKNF VCCAVCNKII PPAPFGKTFK RIHEYKPLKT RFYTHKDILD IGANILKKEE
    61  QFQEDILREH IAKAEAEVWA QANERQKQAV EKALEEANDR HKIEIQILKE EHQKDLQEVT
   121  AKTKTEMYQN MDDEMKREHL AAEQRMVHRI QRIMMECHRE KVEAVEKARA EERHIAQEAI
   181  QAQKSKAVEE IVNTGVTVIK DEKTSVARLM REKEHEMSIL YGIAQRQRQE EVQEVLQEAE
   241  KTHQATLGNM MDKLANTQGE LLSIAKQLGI MTNWKDFLEE ELQETRMAFQ KYINYTFPKL
   301  SPGHADFILP ERKKTPSNLV IKENKTTLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C6orf163 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 7.2 nTPM

Expression across tissuesHPA

Tissue

testis: 7.2 nTPM
bone marrow: 2.2 nTPM
skin: 1.5 nTPM
fallopian tube: 1.4 nTPM
epididymis: 1.3 nTPM
skeletal muscle: 1.2 nTPM

Single-cell type

early spermatids: 16 nCPM
late spermatids: 15 nCPM
late primary spermatocytes: 1.2 nCPM
fallopian tube ciliated cells: 0.7 nCPM
endometrial ciliated cells: 0.4 nCPM
epididymal efferent duct ciliated cells: 0.4 nCPM

Immune cell

neutrophil: 0.8 nTPM
gdT-cell: 0.4 nTPM
memory CD4 T-cell: 0.3 nTPM
naive CD4 T-cell: 0.3 nTPM
naive CD8 T-cell: 0.3 nTPM
basophil: 0.2 nTPM

Brain region

cerebral cortex: 9.6 nTPM
choroid plexus: 9.3 nTPM
white matter: 9.1 nTPM
amygdala: 8.6 nTPM
hippocampal formation: 8.5 nTPM
basal ganglia: 8.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0
gnomAD missense Z: 1.33
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Uncharacterized protein C6orf163

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C6orf163 as an antibody target. Whether an autoantibody or antibody against C6orf163 could matter depends on whether native C6orf163 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C6orf163 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C6orf163 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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