Seroatlas · Human Serome Atlas

C6orf15

Uncharacterized protein C6orf15

Also known as: CF015_HUMAN, STG

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UXA7
Gene: C6orf15
Ensembl: ENSG00000204542
Chromosome: 6
Canonical length: 325 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

Predicted to enable several functions, including collagen V binding activity; fibronectin binding activity; and glycosaminoglycan binding activity. Predicted to be involved in extracellular matrix organization. Predicted to be located in interstitial matrix. Predicted to be active in extracellular matrix. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>Q6UXA7|C6orf15
     1  MQGRVAGSCA PLGLLLVCLH LPGLFARSIG VVEEKVSQNL GTNLPQLGQP SSTGPSNSEH
    61  PQPALDPRSN DLARVPLKLS VPASDGFPPA GGSAVQRWPP SWGLPAMDSW PPEDPWQMMA
   121  AAAEDRLGEA LPEELSYLSS AAALAPGSGP LPGESSPDAT GLSPKASLLH QDSESRRLPR
   181  SNSLGAGGKI LSQRPPWSLI HRVLPDHPWG TLNPSVSWGG GGPGTGWGTR PMPHPEGIWG
   241  INNQPPGTSW GNINRYPGGS WGNINRYPGG SWGNINRYPG GSWGNIHLYP GINNPFPPGV
   301  LRPPGSSWNI PAGFPNPPSP RLQWG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C6orf15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.72
Highest tissue expression: 6.3 nTPM

Expression across tissuesHPA

Tissue

skin: 6.3 nTPM
cervix: 5.2 nTPM
tonsil: 3.2 nTPM
pituitary gland: 1.1 nTPM
thymus: 0.8 nTPM
vagina: 0.6 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 0.2 nTPM
medulla oblongata: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0.01
gnomAD missense Z: 1.12
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

extracellular matrix organization

Cellular components

extracellular matrix

Protein domainsUniProt · Pfam · InterPro

Uncharacterised protein C6orf15
Simian taste bud-specific gene product family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C6orf15 as an antibody target. Whether an autoantibody or antibody against C6orf15 could matter depends on whether native C6orf15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C6orf15 is annotated as secreted, so native C6orf15 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label C6orf15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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