Seroatlas · Human Serome Atlas

C6orf141

Uncharacterized protein C6orf141

Also known as: CF141_HUMAN, MGC46457

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5SZD1
Gene
C6orf141
Ensembl
ENSG00000197261
Chromosome
6
Canonical length
244 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear membrane

OverviewNCBI Gene

Predicted to act upstream of or within blastocyst hatching. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

244 residues, UniProt reviewed canonical sequence.

>Q5SZD1|C6orf141
     1  MNDPFARMET RGPQGAANPM DSSRSLGDLG PFPREVGRGA PLAPGARNPA TAGASRSQGG
    61  GHEDRTADRA LGPRAGEELD RESWVREKVL FLLHPERWLG TRGDPAREEV AGAEDLPHAG
   121  GEDHGEEPNY PSVFQRQKRI SGRRVAPPRD AADPPKYVLV RVEDYQVTQE VLQTSWAKGR
   181  MTTRTEEHFV TALTFRSSRE GQPGERWGPA ESRALQARTG ASRVHAAGRR VSPSPGTWLE
   241  EIKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C6orf141 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
8 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 8 nTPM
  • duodenum: 6.2 nTPM
  • gallbladder: 5.8 nTPM
  • stomach: 5.1 nTPM
  • salivary gland: 4.2 nTPM
  • breast: 4.1 nTPM

Single-cell type

  • neuroendocrine cells: 102 nCPM
  • pancreatic duct cells: 88 nCPM
  • sertoli cells: 84 nCPM
  • lymphatic endothelial cells: 71 nCPM
  • endometrial glandular cells: 58 nCPM
  • endometrial luminal cells: 51 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 11 nTPM
  • pons: 5.3 nTPM
  • cerebellum: 2.6 nTPM
  • hypothalamus: 2.5 nTPM
  • medulla oblongata: 2.3 nTPM
  • cerebral cortex: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
0.08
DepMap mean gene effect
-0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Uncharacterized protein C6orf141

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C6orf141 as an antibody target. Whether an autoantibody or antibody against C6orf141 could matter depends on whether native C6orf141 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C6orf141 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C6orf141 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C6orf141. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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